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Related Concept Videos

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Primary Healthcare Services

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Primary care promotes wellness and prevents disease. This care includes health promotion, education, protection (such as immunizations), early disease screening, and environmental considerations. Settings providing this type of healthcare include physician offices, public health clinics, school nursing, and community health nursing.
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Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
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Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
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Healthcare Agencies II01:17

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Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
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Public Health.

Emma Louise Palatsides1, Dibya Himali2, Stephanie Yiallourou3

  • 1School of Psychological Sciences & Turner Institute for Brain and Mental Health, Monash University, Clayton, VIC, Australia.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
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Summary
This summary is machine-generated.

Genetic variations in the aquaporin-4 (AQP4) gene are linked to better memory and larger brain volumes. This AQP4 genetic variation may also reduce the risk of developing dementia.

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Area of Science:

  • Neuroscience
  • Genetics
  • Dementia Research

Background:

  • The aquaporin-4 (AQP4) water channel is crucial for brain waste clearance, including amyloid-beta and tau proteins.
  • The role of genetic variations in the AQP4 gene in dementia development remains largely unknown.
  • This study investigates the association between AQP4 genetic variation and cognitive function, brain structure, and dementia risk.

Purpose of the Study:

  • To examine the relationship between AQP4 gene variations and cognitive performance.
  • To assess the association between AQP4 genetic variation and brain volumes, specifically hippocampal volume.
  • To determine if AQP4 genetic variation influences the risk of developing dementia.

Main Methods:

  • Utilized data from the Framingham Heart Study (FHS) cohorts.
  • Employed linear regression to analyze AQP4 variation's impact on cognition and brain volumes in participants aged 45+.
  • Used Cox proportional hazards regression to evaluate AQP4 variation's association with incident dementia from age 65+ with up to 20-year follow-up.

Main Results:

  • Carriage of the minor AQP4 allele correlated with enhanced verbal episodic memory and larger hippocampal volumes.
  • Individuals with the minor AQP4 allele showed a trend towards reduced risk of incident dementia.
  • Specifically, heterozygotes for the minor allele exhibited a 32% lower risk of Alzheimer's disease dementia from age 75 onwards.

Conclusions:

  • Genetic variation in the AQP4 haplotype is associated with improved episodic memory and larger hippocampal volumes.
  • The minor allele of AQP4 may confer a protective effect against dementia.
  • Further research into AQP4's role could reveal new mechanisms underlying dementia.