Public Health
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View abstract on PubMed
Summary
This summary is machine-generated.Foreign-born individuals showed slightly lower willingness to join Alzheimer's disease (AD) trials compared to US-born participants. Understanding sociocultural factors is key for inclusive AD clinical trial recruitment.
Area Of Science
- Neuroscience
- Clinical Trials
- Sociology
Background
- Racial and ethnic minorities are underrepresented in Alzheimer's disease (AD) preclinical trials.
- Sociocultural factors like assimilation, education, and socioeconomic status may influence trial participation differently between foreign-born and US-born individuals.
- Limited research exists on how nativity impacts decisions to enroll in AD biomarker trials.
Purpose Of The Study
- To explore differences in willingness to learn AD biomarker status and enroll in preclinical AD trials between foreign-born and US-born participants.
- To investigate the influence of sociocultural factors on trial participation decisions.
Main Methods
- Recruited a diverse sample of cognitively unimpaired older adults via community outreach.
- Collected mixed-methods data, including cognitive interviews in English, Spanish, and Korean.
- Utilized a conjoint experiment where participants rated willingness to join 16 trial scenarios (7-point Likert scale).
- Collected sociodemographic data, including country of origin and duration in the US.
- Planned to use linear regression and proportional odds models to analyze the association between nativity and willingness, controlling for covariates.
Main Results
- The study included 263 participants, with 132 foreign-born and 131 US-born.
- Foreign-born participants were more likely to be NH Asian and Hispanic/Latino compared to US-born participants.
- US-born participants reported a mean willingness score of 63.47, while foreign-born participants reported a mean score of 60.3.
Conclusions
- Sociocultural factors influencing trial participation decisions are often overlooked in recruitment strategies.
- Preliminary data suggest potential differences in willingness to participate based on nativity.
- Findings can inform the development of more inclusive and efficient recruitment strategies for AD clinical trials and biomarker disclosure.
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