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Public Health.

Edwin Duran1, Michelle M Nuño2, Megan G Witbracht1

  • 1Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.

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Summary
This summary is machine-generated.

Foreign-born individuals showed slightly lower willingness to join Alzheimer's disease (AD) trials compared to US-born participants. Understanding sociocultural factors is key for inclusive AD clinical trial recruitment.

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Area of Science:

  • Neuroscience
  • Clinical Trials
  • Sociology

Background:

  • Racial and ethnic minorities are underrepresented in Alzheimer's disease (AD) preclinical trials.
  • Sociocultural factors like assimilation, education, and socioeconomic status may influence trial participation differently between foreign-born and US-born individuals.
  • Limited research exists on how nativity impacts decisions to enroll in AD biomarker trials.

Purpose of the Study:

  • To explore differences in willingness to learn AD biomarker status and enroll in preclinical AD trials between foreign-born and US-born participants.
  • To investigate the influence of sociocultural factors on trial participation decisions.

Main Methods:

  • Recruited a diverse sample of cognitively unimpaired older adults via community outreach.
  • Collected mixed-methods data, including cognitive interviews in English, Spanish, and Korean.
  • Utilized a conjoint experiment where participants rated willingness to join 16 trial scenarios (7-point Likert scale).
  • Collected sociodemographic data, including country of origin and duration in the US.
  • Planned to use linear regression and proportional odds models to analyze the association between nativity and willingness, controlling for covariates.

Main Results:

  • The study included 263 participants, with 132 foreign-born and 131 US-born.
  • Foreign-born participants were more likely to be NH Asian and Hispanic/Latino compared to US-born participants.
  • US-born participants reported a mean willingness score of 63.47, while foreign-born participants reported a mean score of 60.3.

Conclusions:

  • Sociocultural factors influencing trial participation decisions are often overlooked in recruitment strategies.
  • Preliminary data suggest potential differences in willingness to participate based on nativity.
  • Findings can inform the development of more inclusive and efficient recruitment strategies for AD clinical trials and biomarker disclosure.