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Alzheimer's Imaging Consortium.

Taylor W Schmitz1

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Summary
This summary is machine-generated.

Cross-species cognitive testing using touchscreen Continuous Performance Tasks (CPT) aids Alzheimer's disease (AD) research. This approach links genetic risk, cognitive performance, and neurobiology to understand early AD mechanisms.

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Area of Science:

  • Neuroscience
  • Genetics
  • Cognitive Science

Background:

  • Cross-species cognitive testing advances Alzheimer's disease (AD) understanding.
  • Mouse models provide causal insights into genetic and biological factors influencing cognitive decline.
  • Touchscreen cognitive tasks bridge preclinical and clinical research by enabling consistent human and mouse testing.

Purpose of the Study:

  • To integrate homologous touchscreen cognitive tests in parallel studies of AD mouse models and humans at risk for AD.
  • To explore how genetic factors (amyloid, tau, ApoE genotype) interact with age and sex in executive function using the Continuous Performance Task (CPT).
  • To investigate the sensitivity of touchscreen cognitive tests to early AD-related decline compared to standard neuropsychological tests.

Main Methods:

  • Utilizing homologous touchscreen tests, including the CPT, in next-generation AD mouse models and humans at risk for AD.
  • Employing mouse models with humanized knock-in genes (amyloid, tau, ApoE ε3/ε4) to study genetic interactions with age and sex.
  • Integrating the CPT into the longitudinal PREVENT-AD study, collecting data from over 425 individuals with intact cognition and a family history of AD.

Main Results:

  • The CPT has been integrated into the PREVENT-AD study, with data acquired from over 220 individuals.
  • Longitudinal CPT data has been collected from approximately 80 participants in the PREVENT-AD cohort.
  • The study leverages comprehensive datasets including neuroimaging, biomarkers, and cognitive assessments from the PREVENT-AD cohort.

Conclusions:

  • Touchscreen-based cognitive testing in humans and mice elucidates AD risk mechanisms.
  • PREVENT-AD human and mouse CPT data can reveal interactions between ApoE genotype, age, and sex in early cognitive dysfunction.
  • Expanding touchscreen tests in large-scale consortia will link genetic risk, cognitive performance, and neurobiological markers to advance AD understanding and interventions.