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Related Concept Videos

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Primary care promotes wellness and prevents disease. This care includes health promotion, education, protection (such as immunizations), early disease screening, and environmental considerations. Settings providing this type of healthcare include physician offices, public health clinics, school nursing, and community health nursing.
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Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
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Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
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Public Health.

Diandra N Denier-Fields1, Ruocheng Dong1, Briana L Rocha1

  • 1University of Wisconsin-Madison, Madison, WI, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
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Summary
This summary is machine-generated.

The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet is linked to specific plasma metabolites that correlate with Alzheimer's disease (AD) and neurodegeneration biomarkers. These findings suggest diet influences dementia risk through metabolic pathways.

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Area of Science:

  • Neuroscience
  • Nutritional Science
  • Biochemistry

Background:

  • Plasma biomarkers like ptau217, Aβ42/40, GFAP, and NfL indicate Alzheimer's disease (AD), neuroinflammation, and neurodegeneration.
  • The MIND diet is a lifestyle factor associated with reduced dementia risk.
  • Plasma metabolomics offers an objective measure of dietary impact, complementing traditional questionnaires.

Purpose of the Study:

  • To investigate the associations between the MIND diet score, plasma metabolites, and key plasma biomarkers of AD and neurodegeneration.
  • To identify specific plasma metabolites linked to the MIND diet and their relationship with dementia biomarkers.

Main Methods:

  • Utilized data from 1,104 cognitively unimpaired participants in the Wisconsin Registry for Alzheimer's Prevention (WRAP) cohort.
  • Identified 72 plasma metabolites associated with the MIND diet score.
  • Applied Principal Component Analysis (PCA) to metabolite data and general linear regression to assess associations with plasma biomarkers (ptau217, Aβ42/40, GFAP, NfL), adjusting for age, sex, and APOE.

Main Results:

  • Four principal components (PCs) explained 38% of the variance in MIND diet-associated metabolites.
  • Significant positive associations were found between metabolite PCs and plasma biomarkers: PC1 with ptau217 and NfL; PC2 with GFAP and NfL; PC3 with all four biomarkers; PC4 with ptau217.

Conclusions:

  • Groups of plasma metabolites associated with the MIND diet correlate with biomarkers of AD and neurodegeneration.
  • These metabolite groups include essential amino acids, omega-3 fatty acids, plant/gut microbe-derived metabolites, and sphingolipids.
  • Dietary interventions may modulate metabolic pathways relevant to dementia biomarkers.