Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Primary Healthcare Services01:30

Primary Healthcare Services

1.9K
Primary care promotes wellness and prevents disease. This care includes health promotion, education, protection (such as immunizations), early disease screening, and environmental considerations. Settings providing this type of healthcare include physician offices, public health clinics, school nursing, and community health nursing.
In 1978, international leaders convened in Alma-Ata, Kazakhstan, for what would be a pivotal event in global health. The Alma-Ata Declaration was the first to call...
1.9K
Levels of Health Promotion and Illness Prevention01:26

Levels of Health Promotion and Illness Prevention

14.1K
Health promotion allows a person to control the determinants of health, resulting in an improved health status. It enhances the quality of life and reduces premature deaths. Health promotion and illness prevention programs help people make beneficial choices to reduce the risk of disease and disabilities. There are three health promotion and illness prevention levels: primary, secondary, and tertiary prevention.
In primary prevention, actions taken before disease onset prevent the disease from...
14.1K
Preventive Healthcare Services01:30

Preventive Healthcare Services

1.8K
Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
1.8K
Principles of Disease Surveillance01:26

Principles of Disease Surveillance

439
Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
439
Healthcare Agencies II01:17

Healthcare Agencies II

1000
There are various healthcare agencies in the United States—some of which are managed by religious institutions and others by different government branches.
Parish nursing is a growing specialty nursing profession that focuses on holistic healthcare, health promotion, and illness prevention. It blends professional nursing practice with a health ministry, focusing on health and healing within the context of a Christian community. Parish nurses serve as health educators, referral sources,...
1000
Methods Of Healthcare Delivery System01:26

Methods Of Healthcare Delivery System

3.9K
At the different levels of the healthcare system, we see varying methods of healthcare used. These methods include managed care systems, case management, and primary healthcare.
Managed Care System:
The managed care system is designed to control the cost while maintaining the quality of care. The patient's care from admission to discharge is planned by the primary care provider or the case manager, also known as the gatekeeper. In a managed care system, the number of care providers is...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Influence of an AQP4 haplotype and sleep duration on early Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Non-linear associations between sleep duration and plasma p-tau181 in the Framingham Heart Study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Sex-specific trends in incident stroke: The Framingham Heart Study.

medRxiv : the preprint server for health sciences·2026
Same author

Association Between Nerve Growth Factor and Clinical Stroke and Covert Brain Infarcts: The FHS.

Journal of the American Heart Association·2026
Same author

Ischemic Stroke Incidence and Severity and Poststroke Cognitive Decline and Incident Dementia.

JAMA network open·2026
Same author

Association of Circulating Vitamin D in Midlife With Increased Tau-PET Burden in Dementia-Free Adults.

Neurology open access·2026
Same journal

Evidence for progressive neurodegeneration in iatrogenic cerebral amyloid angiopathy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Human brain connectome profiles mediate the relationship between pathology burden and clinical phenotypes in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Kat5 cKO mouse replicates biological domain signatures associated with Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Evaluation of CSF and plasma tau species as fluid surrogate candidates for tau PET in prodromal to moderate Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Associations of self-reported obstructive sleep apnea with cognition and dementia risk in cognitively unimpaired middle-aged adults.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Inflammation profiles in Alzheimer's disease relate to cognition and neurodegeneration.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
See all related articles

Related Experiment Video

Updated: Jan 8, 2026

Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
10:57

Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children

Published on: August 22, 2012

24.2K

Public Health.

Yannick Joel Wadop Ngouongo1, Jazmyn A Muhammad2, Rebecca Bernal3

  • 1Glenn Biggs Institute for Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
PubMed
Summary
This summary is machine-generated.

Improving cardiovascular health through Life's Essential 8 (LE8) adherence positively impacts gut microbiome diversity and cognitive function. Specific gut bacteria mediate this beneficial gut-brain axis connection.

More Related Videos

Visualizing Field Data Collection Procedures of Exposure and Biomarker Assessments for the Household Air Pollution Intervention Network Trial in India
09:33

Visualizing Field Data Collection Procedures of Exposure and Biomarker Assessments for the Household Air Pollution Intervention Network Trial in India

Published on: December 23, 2022

2.6K
Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

Related Experiment Videos

Last Updated: Jan 8, 2026

Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
10:57

Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children

Published on: August 22, 2012

24.2K
Visualizing Field Data Collection Procedures of Exposure and Biomarker Assessments for the Household Air Pollution Intervention Network Trial in India
09:33

Visualizing Field Data Collection Procedures of Exposure and Biomarker Assessments for the Household Air Pollution Intervention Network Trial in India

Published on: December 23, 2022

2.6K
Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

Area of Science:

  • Microbiome research
  • Neuroscience
  • Cardiovascular health

Background:

  • Cardiovascular health, gut microbiome, and cognitive function are intricately linked.
  • Life's Essential 8 (LE8) provides key metrics for cardiovascular health.
  • Understanding the interplay between LE8, the gut microbiome, and cognition is crucial.

Purpose of the Study:

  • To investigate the association between adherence to Life's Essential 8 (LE8) metrics and gut microbiota composition.
  • To explore the relationship between LE8 adherence, gut microbial diversity, and cognitive performance.
  • To identify potential mediating roles of gut bacteria in the LE8-cognition pathway.

Main Methods:

  • Utilized stool samples, LE8 metrics, and cognitive assessments from 781 Framingham Heart Study participants.
  • Employed multivariable linear regression to analyze associations between LE8 adherence, gut diversity, and cognitive scores.
  • Conducted mediation analyses to determine if specific bacterial taxa mediate the LE8-cognition relationship.

Main Results:

  • Higher LE8 adherence correlated with increased gut microbial diversity (alpha and beta) and favorable genera (Barnesiella, Ruminococcus).
  • Beneficial gut microbial diversity and specific genera (e.g., Oscillospira) were linked to better global cognitive scores.
  • Gut bacteria, including Barnesiella and Lentisphaerae, were identified as mediators in the association between LE8 adherence and cognitive performance.

Conclusions:

  • The gut microbiome acts as a significant mediator connecting cardiovascular health (LE8 adherence) and cognitive function.
  • Findings underscore the importance of integrated interventions targeting both cardiovascular and cognitive health.
  • Future research should focus on longitudinal studies and RCTs to confirm causality and explore clinical applications.