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Alzheimer's Imaging Consortium.

Firoza Z Lussier1, Guilherme Povala1, Guilherme Bauer-Negrini1

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Summary
This summary is machine-generated.

The HEAD study is generating a unique dataset of tau-PET tracers (MK-6240, Flortaucipir, RO948, PI-2620) to standardize Alzheimer's disease quantification. This head-to-head comparison aims to harmonize outcomes and guide future clinical trials.

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Area of Science:

  • Neuroimaging
  • Biomarker Discovery
  • Alzheimer's Disease Research

Background:

  • Standardizing in vivo tau pathology quantification is crucial for Alzheimer's disease (AD) research but is challenged by tau-PET tracer variability.
  • The HEAD study was initiated to address this by creating a comprehensive, longitudinal head-to-head dataset of multiple tau-PET tracers.

Purpose of the Study:

  • To harmonize outcomes from different tau-PET tracers, including MK-6240, Flortaucipipr, RO948, and PI-2620.
  • To develop tools for generalizing findings across various studies and clinical trials.
  • To provide an update on the progression of the HEAD study's data generation.

Main Methods:

  • A multicentric study involving nine performance sites, aiming to recruit 620 participants across different age groups and cognitive statuses (Young, Cognitively Unimpaired, Mild Cognitive Impairment, Dementia).
  • Standardized clinical assessments, blood collection for biomarker banking, MRI acquisition, and amyloid-PET scans.
  • Head-to-head tau-PET imaging with at least two tracers per participant, utilizing uniform data processing protocols.

Main Results:

  • Over 26 months, 679 participants were enrolled, exceeding the target by 9.5%.
  • Data collection is progressing, with 81% of enrolled participants completing their initial timepoint and 1,489 head-to-head tau-PET scans acquired.
  • Longitudinal data collection has commenced, with initial 18-month follow-ups initiated for a subset of participants.

Conclusions:

  • The HEAD study cohort is a significant contribution to optimizing AD imaging biomarkers.
  • Ongoing cross-sectional and longitudinal data collection, alongside comprehensive plasma biomarker measurements, will yield crucial insights.
  • Findings from the HEAD cohort data will offer essential guidance for the clinical application of tau-PET tracers.