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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
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Updated: Jan 8, 2026

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
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Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

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Alzheimer's Imaging Consortium.

Gemma Salvadó1,2, Kanta Horie3,4,5,6, Nicolas R Barthélemy6,7

  • 1Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Lund, Sweden.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
PubMed
Summary
This summary is machine-generated.

A new Alzheimer's disease (AD) staging system uses plasma %p-tau217 and eMTBR-tau243 biomarkers. This non-invasive method accurately reflects AD progression and is a scalable alternative to PET scans.

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Area of Science:

  • Neurology
  • Biomarker Discovery
  • Alzheimer's Disease Research

Background:

  • Accurate staging of biological Alzheimer's disease (AD) is crucial for clinical trials and treatment development.
  • Current plasma biomarkers lack specificity for advanced AD stages.
  • A need exists for scalable, low-invasive AD staging methods.

Purpose of the Study:

  • To develop and validate a novel staging system for biological Alzheimer's disease using plasma biomarkers.
  • To assess the utility of plasma %p-tau217 and eMTBR-tau243 for non-invasive AD staging.

Main Methods:

  • 764 individuals across the AD continuum were included.
  • Plasma %p-tau217 and eMTBR-tau243 were measured via mass spectrometry.
  • A combined biomarker system created plasma-based stages (Stage-0 to Stage-5) compared to PET imaging and cognitive measures.

Main Results:

  • Plasma %p-tau217 levels preceded eMTBR-tau243 increases, indicating sequential pathology.
  • Higher plasma biomarker stages correlated with advanced AD imaging and clinical features.
  • The plasma-based staging accurately predicted amyloid-β and tau PET positivity.

Conclusions:

  • Combining plasma %p-tau217 and eMTBR-tau243 enables accurate biological staging of AD.
  • This plasma-based approach is non-invasive, scalable, and practical.
  • It offers a viable alternative to CSF or PET-based staging methods.