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Summary
This summary is machine-generated.

Tau pathology preferentially affects brain sulci, particularly their depths, leading to atrophy and memory impairment in Alzheimer's disease. This sulcal vulnerability may be linked to increased tau accumulation and hippocampal connectivity.

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Area of Science:

  • Neuroimaging
  • Neurodegeneration
  • Cognitive Neuroscience

Background:

  • Prior research indicates sulci are uniquely affected by aging and Alzheimer's disease (AD) pathology.
  • The specific vulnerability of sulci to tau pathology and its cognitive impact remain unclear.
  • Hypotheses suggest sulcal depths, with unique connectivity, may be particularly susceptible.

Purpose of the Study:

  • To investigate whether tau-related atrophy preferentially affects brain sulci and their depths.
  • To examine the relationship between tau accumulation, cortical thinning, and cognitive function in AD and MCI.
  • To explore the role of hippocampal connectivity in tau-related vulnerability.

Main Methods:

  • Utilized 3T MRI and tau-PET scans from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort.
  • Correlated neocortical tau SUVR with cortical thickness, analyzing overlap with gyri, sulci, and sulcal depths.
  • Examined the association between tau-related atrophy clusters and memory performance, alongside postmortem tau quantification and resting-state connectivity analysis.

Main Results:

  • Tau-associated cortical thinning significantly overlapped with sulci, especially sulcal depths (p<0.0001).
  • Sulcal regions exhibited higher tau-related t-values compared to gyral regions (p<0.001).
  • The volume of tau-affected clusters strongly predicted memory performance (p=0.02) and showed higher hippocampal connectivity.

Conclusions:

  • Tau-related cortical thinning predominantly occurs in sulci, particularly their depths.
  • This sulcal vulnerability is potentially driven by increased tau accumulation and enhanced hippocampal connectivity within these regions.
  • Findings highlight sulci as critical areas affected by tau pathology in Alzheimer's disease.