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Updated: Jan 7, 2026
10:57
Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
Published on: August 22, 2012
24.2K
Public Health
Xiaoying Chen1, Katie Harris2, Wang Ruirui1
1The George Institute for Global Health, Sydney, NSW, Australia.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
Summary
Antihypertensive treatment appears to reduce dementia risk in individuals aged 60-80, regardless of frailty levels. However, trial data may not fully represent those with severe frailty.
Area of Science:
- Gerontology
- Neurology
- Cardiology
Background:
- High blood pressure (HBP) is a known risk factor for dementia.
- Antihypertensive treatment in individuals aged 60-80 reduces dementia risk.
- Frailty may influence the relationship between HBP and dementia.
Purpose of the Study:
- To investigate frailty as a moderator of antihypertensive treatment's effect on incident dementia.
- To analyze data from four major antihypertensive drug trials.
Main Methods:
- Individual-participant-data meta-analysis of 24,122 participants.
- Frailty Index (FI) used, modeled as continuous and binary (FI ≤ 0.21 vs. FI > 0.21).
- Multilevel multinomial regression accounting for the competing risk of death.
Main Results:
- No significant interaction between frailty and antihypertensive treatment on dementia risk (p=0.47).
- Odds ratios for antihypertensive treatment effect were similar for non-frail (0.88) and frail (0.85) groups.
- Data included participants with a median age of 68.5 years and median follow-up of 4.5 years.
Conclusions:
- Antihypertensive treatment likely benefits dementia risk reduction across frailty levels in those aged 60-80.
- Generalizability to severely frail populations is limited due to trial participant bias.
- Findings have implications for cardiovascular prevention and dementia risk management guidelines.
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