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Updated: Jan 8, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Two new prenyl-substituted natural products from the endophytic fungus Talaromyces sp. XSJC-F4
Shangfeng Gao1,2, Yiqing Shi1,2, Haidi Li1,2
1Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, People's Republic of China.
Abstract:
Two new prenyl-substituted natural products, 10-(3'-methyl-2'-butenyl)-9-methylguanine (1) and 12-ketone-colletorin B (2), along with three known prenylated compounds-12-ketone-colletochlorin B (3), colletorin B (4), and colletochlorin B (5)-were isolated from the endophytic fungus Talaromyces sp. XSJC-F4. The structures of isolated compounds were identified by HRESIMS, NMR analysis, and compared with data from the literature. In addition, all compounds were evaluated for their antibacterial activities in vitro. All five compounds (1-5) exhibited good antibacterial activity against Bacillus subtilis with MIC values ranging from 8 to 64 μg/mL.
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