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Summary
This summary is machine-generated.

Physical activity may protect cognitive function in postmenopausal women, especially those with the Met allele and earlier menopause. Staying active can mitigate risks associated with menopause timing and genetic factors influencing brain health.

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Area of Science:

  • Neuroscience
  • Genetics
  • Gerontology

Background:

  • Early menopause is linked to cognitive decline and dementia.
  • The BDNF Val66Met polymorphism (Met allele) is associated with reduced brain-derived neurotrophic factor and poorer cognitive outcomes.
  • Physical activity may enhance BDNF levels, potentially counteracting cognitive deficits from early menopause or Met allele carriage.

Purpose of the Study:

  • To investigate the interactive effects of age at menopause, BDNF genotype (Met carriage), and physical activity on cognitive function in postmenopausal women.
  • To determine if physical activity can mitigate the negative cognitive impacts of early menopause and the BDNF Met allele.

Main Methods:

  • Utilized baseline data from the Canadian Longitudinal Study on Aging (N=8,101 postmenopausal women).
  • Assessed BDNF Val66Met genotype, self-reported age at menopause, and physical activity using the PASE score.
  • Analyzed global cognition using neuropsychological tests and linear regression models, adjusting for covariates.

Main Results:

  • Earlier menopause and lower physical activity were independently associated with worse cognitive scores.
  • BDNF Met carriage alone did not significantly impact cognition.
  • A significant three-way interaction revealed that higher physical activity attenuated the negative cognitive effects of earlier menopause in Met carriers, but not in non-carriers.

Conclusions:

  • Age at menopause, BDNF genotype, and physical activity interact to influence cognitive function in postmenopausal women.
  • Physical activity appears particularly beneficial for preserving cognitive health in women who experience early menopause and carry the BDNF Met allele.