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Updated: Jan 8, 2026

Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
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Public Health.

Yi Zhao1, Liangjun Dang2, Suhang Shang2

  • 1The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, shaanxi, China.

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|December 23, 2025
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Summary
This summary is machine-generated.

High homocysteine (Hcy) levels are associated with increased cognitive impairment risk in Chinese adults. Further intervention studies are needed to confirm these findings and explore Hcy reduction strategies.

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Area of Science:

  • Neurology
  • Cardiovascular Health
  • Gerontology

Background:

  • High plasma homocysteine (Hcy) is a known risk factor for cardiovascular disease and stroke.
  • The specific impact of plasma Hcy on cognitive impairment remains under-investigated, particularly in Asian populations.

Purpose of the Study:

  • To investigate the association between plasma Hcy levels and cognitive impairment in a middle-aged and older Chinese population.
  • To determine if elevated Hcy is an independent risk factor for cognitive decline.

Main Methods:

  • A community-based cross-sectional study involving 1,805 participants (≥ 40 years) in Xi'an, China.
  • Cognitive function assessed using the Mini-Mental State Examination (MMSE) and neuropsychological scales; cognitive impairment diagnosed by established criteria.
  • Plasma Hcy levels categorized into tertiles; multivariable logistic regression and restricted cubic splines used for analysis.

Main Results:

  • The prevalence of cognitive impairment was 8.0% (145/1805), increasing significantly with higher Hcy tertiles (4.9% to 12.2%).
  • Elevated Hcy levels were independently associated with a higher risk of cognitive impairment (OR=1.029 per unit increase, p=0.001).
  • High Hcy levels (compared to low) showed a significantly increased risk (OR=1.89, p=0.010), with no non-linear relationship detected.

Conclusions:

  • Elevated plasma Hcy levels are significantly linked to an increased likelihood of cognitive impairment in this population.
  • Further cohort intervention studies focusing on Hcy reduction are necessary to confirm causality and explore therapeutic strategies.