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Agitation in Alzheimer

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Area of Science:

  • Geriatric Psychiatry
  • Neuroscience
  • Clinical Psychology

Background:

  • Agitation is a common and distressing symptom in Alzheimer's disease (AD).
  • Understanding the multifactorial influences on agitation is crucial for effective management.
  • Identifying modifiable factors can lead to targeted interventions.

Purpose of the Study:

  • To investigate the impact of caregiver, environmental, and individual factors on agitation in AD patients.
  • To identify key modifiable factors associated with agitation symptoms.

Main Methods:

  • A cohort of 110 Alzheimer's disease patients and their primary caregivers were recruited.
  • Data collection included patient neuropsychological tests (MMSE, GDS), caregiver assessments (NPI, Hamilton Scales), environmental questionnaires, and agitation severity (Cohen-Mansfield Agitation Inventory).
  • Statistical analyses examined differences between agitated and non-agitated groups and identified factors associated with agitation.

Main Results:

  • Over half (56.36%) of AD patients exhibited agitation.
  • Agitation was associated with male patients, female caregivers, lack of courtyard/garden views, lower MMSE scores, and lower GDS scores.
  • Protective factors against agitation included rooms with courtyard/garden views, male caregivers, and higher MMSE scores.

Conclusions:

  • Improving the living environment, encouraging male caregivers, and enhancing caregiver support can reduce agitation in AD.
  • Multifactorial interventions involving healthcare professionals, communities, and families are recommended.
  • Targeting modifiable factors offers a promising approach to managing agitation in Alzheimer's disease.