Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Primary Healthcare Services01:30

Primary Healthcare Services

1.9K
Primary care promotes wellness and prevents disease. This care includes health promotion, education, protection (such as immunizations), early disease screening, and environmental considerations. Settings providing this type of healthcare include physician offices, public health clinics, school nursing, and community health nursing.
In 1978, international leaders convened in Alma-Ata, Kazakhstan, for what would be a pivotal event in global health. The Alma-Ata Declaration was the first to call...
1.9K
Levels of Health Promotion and Illness Prevention01:26

Levels of Health Promotion and Illness Prevention

14.1K
Health promotion allows a person to control the determinants of health, resulting in an improved health status. It enhances the quality of life and reduces premature deaths. Health promotion and illness prevention programs help people make beneficial choices to reduce the risk of disease and disabilities. There are three health promotion and illness prevention levels: primary, secondary, and tertiary prevention.
In primary prevention, actions taken before disease onset prevent the disease from...
14.1K
Preventive Healthcare Services01:30

Preventive Healthcare Services

1.8K
Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
1.8K
Principles of Disease Surveillance01:26

Principles of Disease Surveillance

439
Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
439
Healthcare Agencies II01:17

Healthcare Agencies II

1000
There are various healthcare agencies in the United States—some of which are managed by religious institutions and others by different government branches.
Parish nursing is a growing specialty nursing profession that focuses on holistic healthcare, health promotion, and illness prevention. It blends professional nursing practice with a health ministry, focusing on health and healing within the context of a Christian community. Parish nurses serve as health educators, referral sources,...
1000
Methods Of Healthcare Delivery System01:26

Methods Of Healthcare Delivery System

3.9K
At the different levels of the healthcare system, we see varying methods of healthcare used. These methods include managed care systems, case management, and primary healthcare.
Managed Care System:
The managed care system is designed to control the cost while maintaining the quality of care. The patient's care from admission to discharge is planned by the primary care provider or the case manager, also known as the gatekeeper. In a managed care system, the number of care providers is...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Malleable Beliefs Matter: Essentialist Beliefs About Aging and Mental Health Among Community-Dwelling Older Adults.

Clinical gerontologist·2026
Same author

SWI and T2*-GRE Microhemorrhage Counts in Anti-Amyloid Therapy Eligibility: A Real-World-Calibrated Simulation Study.

medRxiv : the preprint server for health sciences·2026
Same author

Study partner profile effects on CDR-SB change in anti-amyloid therapy evaluation.

medRxiv : the preprint server for health sciences·2026
Same author

Potential and biases of large language model simulation for public surveys on Alzheimer's disease therapies.

Journal of Alzheimer's disease : JAD·2026
Same author

Provider and patient perspectives on the diagnosis and treatment of Alzheimer's disease: A global perspective from the Global Alzheimer's Leadership Series (GoALS).

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Aortic dissection after sutureless valve and chest compressions.

Asian cardiovascular & thoracic annals·2026

Related Experiment Video

Updated: Jan 8, 2026

Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
10:57

Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children

Published on: August 22, 2012

24.2K

Public Health.

Saki Nakashima1, Kenichiro Sato2,3, Yoshiki Niimi4,5

  • 1Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
PubMed
Summary

Early Alzheimer's disease patients with higher Clinical Dementia Rating-Global Scores (CDR-GS) and lower Mini-Mental State Examination (MMSE) scores have a shorter window for disease-modifying therapies (DMTs). Understanding these predictors optimizes treatment timing and resource allocation.

More Related Videos

Visualizing Field Data Collection Procedures of Exposure and Biomarker Assessments for the Household Air Pollution Intervention Network Trial in India
09:33

Visualizing Field Data Collection Procedures of Exposure and Biomarker Assessments for the Household Air Pollution Intervention Network Trial in India

Published on: December 23, 2022

2.6K
Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

Related Experiment Videos

Last Updated: Jan 8, 2026

Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
10:57

Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children

Published on: August 22, 2012

24.2K
Visualizing Field Data Collection Procedures of Exposure and Biomarker Assessments for the Household Air Pollution Intervention Network Trial in India
09:33

Visualizing Field Data Collection Procedures of Exposure and Biomarker Assessments for the Household Air Pollution Intervention Network Trial in India

Published on: December 23, 2022

2.6K
Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

Area of Science:

  • Neurology
  • Gerontology
  • Pharmacology

Background:

  • Lecanemab and donanemab are approved disease-modifying therapies (DMTs) for early Alzheimer's disease (AD).
  • Eligibility for these DMTs requires amyloid positivity, specific Clinical Dementia Rating-Global Score (CDR-GS) and Mini-Mental State Examination (MMSE) ranges.
  • The gradual progression of AD creates a limited therapeutic time window, necessitating an understanding of eligibility duration.

Purpose of the Study:

  • To determine the duration of eligibility for early AD DMTs.
  • To identify baseline predictors of time to ineligibility for Lecanemab and Donanemab.
  • To inform clinical workflows and optimize patient selection for timely treatment.

Main Methods:

  • Analysis of two longitudinal cohorts: National Alzheimer's Coordinating Center (NACC) and Alzheimer's Disease Neuroimaging Initiative (ADNI).
  • Inclusion of participants meeting CDR-GS and MMSE criteria with confirmed amyloid positivity.
  • Cox proportional hazards models used to assess baseline variables (MMSE, CDR-GS, age, tau) predicting time to ineligibility.

Main Results:

  • Higher baseline CDR-GS (1 vs. 0.5) and lower baseline MMSE scores significantly predicted shorter eligibility periods.
  • Participants with CDR-GS of 1 had nearly double the risk of early ineligibility compared to CDR-GS of 0.5 (HR=1.99).
  • Median eligibility was shorter for CDR-GS 1 (approx. 12 months) versus CDR-GS 0.5 with higher MMSE (up to 24 months).

Conclusions:

  • Baseline CDR-GS and MMSE are critical predictors of remaining within the therapeutic time window for early AD DMTs.
  • These findings aid clinicians in prioritizing patients at higher risk of losing eligibility.
  • Informed scheduling decisions can optimize the use of healthcare resources and prevent missed treatment opportunities.