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Updated: Jan 8, 2026

Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
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Public Health.

Svetlana Ukraintseva1, Hongzhe Duan1, Rachel Holmes1

  • 1Duke University, Durham, NC, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
PubMed
Summary
This summary is machine-generated.

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Shingles vaccination before age 75 is linked to reduced Alzheimer's disease (AD) risk, particularly in female carriers of a specific genetic risk factor. Early vaccination may offer greater AD protection.

Area of Science:

  • Neuroscience
  • Immunology
  • Genetics

Background:

  • Previous research indicated a ~20% reduced risk of Alzheimer's disease (AD) following shingles vaccination.
  • This study investigates genotype-specific associations between shingles vaccination and AD risk.

Purpose of the Study:

  • To examine the association between shingles vaccination and the odds of developing Alzheimer's disease (AD).
  • To explore genotype-specific effects, particularly in relation to the rs6859 (A) allele, a known AD risk factor.

Main Methods:

  • Logistic regression models were used to analyze data from the Health and Retirement Study (HRS) and UK Biobank (UKB).
  • Participants aged 65-75 who received the shingles vaccine were compared to unvaccinated individuals.
  • Analyses were stratified by carrier status of the rs6859 (A) allele, a genetic risk factor for AD.

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Main Results:

  • Shingles vaccination at ages 65-75 was associated with significantly lower odds of AD onset after age 75 (OR=0.55).
  • The protective association was stronger in carriers of the rs6859 (A) allele (OR=0.44), especially in females (OR=0.28).
  • Vaccination three or more years before age 75 showed greater risk reduction compared to vaccination within two years.

Conclusions:

  • Shingles vaccination before age 75 is associated with reduced odds of later-life AD.
  • The protective effect is more pronounced in female carriers of the rs6859 (A) allele.
  • Personalized repurposing of the shingles vaccine for AD prevention is supported, with earlier vaccination potentially offering enhanced protection.