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Updated: Jan 8, 2026
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Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
Published on: August 22, 2012
24.2K
Public Health
Xue Zhong1, Gengjie Jia2, Zhijun Yin3
1Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
Summary
Managing health conditions like diabetes and sleep disorders may reduce Alzheimer's disease (AD) risk. Identifying these conditions early can promote brain health and potentially halve AD incidence.
Area of Science:
- Neuroscience
- Genetics
- Public Health
Background:
- Effective management of certain health conditions can promote brain health and reduce Alzheimer's disease (AD) risk.
- A five-year delay in AD onset could decrease population incidence by 50%.
Purpose of the Study:
- To systematically identify medical conditions associated with the subsequent development of Alzheimer's disease (AD).
- To discover and validate health conditions that occur more frequently in individuals who later develop AD.
- To assess the connection between enriched phenotypes and AD genetics.
Main Methods:
- Utilized electronic health records (EHRs) from two independent databases (over 153 million individuals).
- Tracked EHRs for 10 years prior to AD diagnosis, comparing condition prevalence between AD cases and matched controls.
- Assessed phenotype-AD genetics connections using large-scale biobanks (BioVU and UK Biobank).
Main Results:
- Identified over 70 medical conditions consistently associated with higher AD incidence across databases.
- Confirmed known AD risk factors (hypertension, diabetes, depression) and identified less-reported associations (hypothyroidism).
- Found associations between certain conditions, medications, and AD genetics.
Conclusions:
- Longitudinal EHR analysis robustly identified health conditions linked to increased AD incidence.
- Highlights the importance of managing these identified health conditions for brain health and AD risk reduction.
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