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Related Concept Videos

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Related Experiment Video

Updated: Jan 8, 2026

Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
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Public Health.

Lauren G Toledo1, Lilah M Besser1, Elaine Le2

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Summary
This summary is machine-generated.

High systemic inflammation is linked to more white matter hyperintensities (WMH), but greater neighborhood tree canopy may reduce this risk. This study explored the independent and interactive effects of inflammation and green space on brain health.

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Area of Science:

  • Neuroscience and Environmental Health
  • Cerebrovascular Health and Public Health

Background:

  • Systemic inflammation is associated with increased white matter hyperintensities (WMH), a risk factor for cerebrovascular disease and dementia.
  • Exposure to neighborhood greenspaces, such as parks, has been linked to reduced inflammation, dementia risk, and fewer WMH.

Purpose of the Study:

  • To investigate the independent associations of systemic inflammation and neighborhood tree canopy with WMH.
  • To examine the interactive effect of systemic inflammation and neighborhood tree canopy on WMH.

Main Methods:

  • Cross-sectional study of 161 participants (≥50 years old) from the Healthy Brain Initiative.
  • Measured neighborhood tree canopy percentage and systemic inflammation using high-sensitivity C-reactive protein (hs-CRP).
  • Quantified white matter hyperintensities (WMH) using structural MRI and analyzed associations using multivariable linear regression.

Main Results:

  • Higher hs-CRP levels were independently associated with greater WMH volume.
  • Increased neighborhood tree canopy percentage was independently associated with reduced WMH volume.
  • Individuals with high hs-CRP and high tree canopy showed lower WMH compared to those with high hs-CRP and low tree canopy.

Conclusions:

  • Both high systemic inflammation and high neighborhood tree canopy show independent associations with WMH.
  • Greater neighborhood tree canopy may mitigate the adverse effects of systemic inflammation on white matter hyperintensities.