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Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
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Public Health.

Julia W Gallini1, Santiago Gutierrez Gomez2, Ashita S Gurnani3

  • 1Boston University School of Public Health, Boston, MA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
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Summary
This summary is machine-generated.

APOE genotype accelerates memory decline in Parkinson's disease (PD) and dementia with Lewy bodies (DLB) patients after mild cognitive impairment (MCI) diagnosis. This finding aids personalized medicine for neurodegenerative diseases.

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Area of Science:

  • Neuroscience
  • Genetics
  • Neurology

Background:

  • Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are common neurodegenerative disorders.
  • Cognitive impairment is prevalent in PD and DLB, but predictors of decline are unclear.
  • This study investigates the impact of APOE genotype and sex on cognitive trajectories in PD and DLB.

Purpose of the Study:

  • To analyze how risk factors, specifically APOE genotype and sex, influence memory, executive function, and language.
  • To characterize cognitive decline trajectories in individuals with PD and DLB.
  • To identify potential biomarkers for predicting cognitive decline in these neurodegenerative conditions.

Main Methods:

  • Utilized National Alzheimer's Coordinating Center data from PD and DLB participants with baseline cognitive assessments.
  • Employed linear mixed-effects models to analyze factor scores for memory, executive function, and language.
  • Included predictors such as sex, race, age, APOE genotype, education, and time since diagnosis, with a focus on the post-mild cognitive impairment (MCI) phase.

Main Results:

  • A faster rate of cognitive decline was observed post-MCI diagnosis across memory, executive function, and language domains.
  • APOE genotype significantly modified memory decline, with individuals carrying 1-2 ε4 alleles declining 0.05 SD/year faster post-MCI.
  • Sex did not significantly modify the rate of cognitive decline post-MCI.

Conclusions:

  • APOE genotype is a significant predictor of accelerated memory decline in PD and DLB patients following an MCI diagnosis.
  • The findings suggest APOE genotype's utility in prognostication for PD/DLB.
  • This research supports a personalized medicine approach for managing cognitive decline in PD and DLB.