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Basic Science and Pathogenesis
Shampa Ghosh1, Krishna Kumar Singh2, Prashant Verma3
1GloNeuro Academy, Noida, Uttar Pradesh, India.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
Summary
Aging disrupts circadian rhythms, accelerating physiological decline and increasing neurodegenerative disease risk. Understanding these connections is key to developing interventions for healthier aging and improved quality of life.
Area of Science:
- Chronobiology
- Neuroscience
- Gerontology
Background:
- Circadian rhythms are vital for physiological homeostasis, regulating metabolism, endocrinology, and cognition.
- Aging significantly disrupts circadian rhythms, leading to altered sleep patterns and accelerated physiological decline.
- These disruptions are linked to increased oxidative stress, inflammation, and are implicated in neurodegenerative disorders.
Purpose of the Study:
- To synthesize research on circadian rhythms and aging.
- To examine how age-associated circadian disruptions contribute to neurodegenerative diseases.
- To review literature connecting circadian health and neurodegeneration via biological clock regulation of metabolic functions.
Main Methods:
- Literature synthesis of current research.
- Examination of age-associated circadian disruptions' role in neurodegeneration.
- Focus on biological clocks' regulation of redox balance and metabolic functions.
Main Results:
- Age-related circadian disruptions predispose to and accelerate neurodegenerative diseases.
- Disruptions deregulate antioxidative and inflammatory responses, impacting neuronal health.
- Altered circadian control affects cognitive and emotional behaviors relevant to Alzheimer's and Parkinson's disease.
Conclusions:
- Understanding circadian rhythm-aging interactions is crucial for interventions against neurodegenerative diseases.
- Targeting circadian disruption may promote healthier aging and delay disease onset.
- Further research in circadian biology and aging can yield novel therapies for elderly populations.
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