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Published on: August 22, 2012
Public Health
Hui Chen1,2, Gulisiya Hailili3, Xue Li3
1Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Background:
MIND diet was favorably linked to lower risk of neurodegenerative diseases. While previous cross-sectional studies implied its beneficial associations with brain imaging markers, its associations with long-term brain structural changes remained unclear.
Method:
We included 1647 middle-aged and older individuals from the Framingham Heart Study Offspring cohort (FOS). MIND diet score was calculated from an extensively validated FFQ in repeatedly administered at Exams 5, 6, and 7 (1991-2001). Brain imaging markers were acquired in 1999-2019, with a median repetition (interquartile range, IQR) of 3 (2, 3) times. We used linear mixed models to assess the associations of the MIND diet score and its components with longitudinal brain structural changes.
Result:
During follow-up (median: 12.3, IQR: 6.8-13.7 years), higher MIND diet score was associated with slower decline in total grey matter volume. Each 3-unit increment was associated with 0.279 cm3/year (95%CI: 0.089, 0.469) cm3/year slower decline in total gray matter volume, which corresponded to 20.1% of the time effect. Higher MIND diet score was also associated with slower increment in lateral ventricle volume (-0.071 cm3/year, 95%CI: -0.125, -0.017), especially left ventricle volume (-0.041 cm3/year, 95%CI: -0.070, -0.013). The estimates corresponded to 8.0% and 8.8% of the time effect, respectively.
Conclusion:
In a community-based prospective study, greater adherence to the MIND diet was related to slower brain atrophy for up to two decades, particularly demonstrated by slower grey matter loss and ventricle expansion. These findings supported the potential brain health benefits of the MIND diet.
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