Public Health
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View abstract on PubMed
Summary
This summary is machine-generated.Latino willingness to join Alzheimer's disease clinical trials is not universally low, but varies by heritage. Culturally tailored strategies addressing safety and logistical concerns are crucial for improving participation.
Area Of Science
- Neuroscience
- Clinical Trials
- Health Disparities
Background
- Latinos are underrepresented in Alzheimer's disease (AD) clinical trials.
- Understanding willingness to participate among diverse Latino subgroups compared to non-Hispanic Whites (NHW) is essential.
Purpose Of The Study
- To examine differences in clinical trial willingness between Latino and NHW adults.
- To identify specific motivators and barriers influencing participation among various Latino heritage groups.
Main Methods
- A web panel survey of 1,800 adults (50+) was conducted, including 1,200 Latinos and 600 NHW participants.
- Willingness to participate in general and AD-specific trials was assessed using Likert scales.
- Multinomial logistic regression analyzed willingness differences, controlling for demographics and family history; secondary analyses explored motivators and barriers.
Main Results
- Overall willingness did not differ between Latinos and NHW, but heritage-specific trends were observed.
- Cuban and Central American participants showed higher willingness, while Dominican and Mexican participants trended lower compared to NHW.
- Motivators and barriers varied significantly by heritage, highlighting the need for tailored approaches; more Latinos expressed greater willingness for AD-focused trials.
Conclusions
- Willingness to participate in AD clinical trials among Latinos is not a uniform barrier.
- Heritage-specific differences necessitate culturally tailored recruitment strategies.
- Addressing safety concerns, logistical barriers, and emphasizing trust and societal benefits can enhance Latino participation.
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