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Updated: Jan 8, 2026

Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
Published on: August 22, 2012
Public Health
Caroline S Duchaine1,2, Manuel Montero-Odasso3,4, Haakon B Nygaard5
1Centre de recherche de l'Institut Universitaire de gériatrie de Montréal (CRIUGM), Montréal, QC, Canada.
Identifying dementia risk profiles helps tailor interventions. Some profiles improved lifestyle factors, but cognitive changes were not linked to these profiles, suggesting a need for more intensive strategies.
Area of Science:
- Neuroscience and Public Health
- Gerontology and Cognitive Aging
Background:
- Dementia risk factors interact, creating unique profiles that may affect intervention effectiveness.
- The CAN-THUMBS-UP Brain Health Support Program (BHSP) provided a platform to study these profiles.
Purpose of the Study:
- Characterize dementia risk profiles within the BHSP.
- Evaluate if these profiles predict participant response to a 45-week educational intervention.
Main Methods:
- Principal component analysis identified three risk profiles based on seven modifiable factors.
- Participants engaged in the Brain Health PRO web-based intervention.
- Lifestyle and cognitive changes were assessed via questionnaires and neuropsychological testing.
Main Results:
- Three distinct profiles emerged: sleep/social/psychological, cognitive engagement, and diet/physical activity/vascular health.
- Lower baseline scores in the first two profiles correlated with greater improvements in those domains.
- Improvements in diet and physical activity were seen in the third profile, but not vascular health; no profile predicted cognitive change.
Conclusions:
- Dementia risk profiles can inform personalized prevention strategies.
- Current online educational interventions may not be sufficient to impact vascular health or cognition.
- Further research is needed to validate and refine these risk profiles.
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