Public Health.

Area of Science:

• Neurology
• Public Health
• Behavioral Science

Background:

• Dementia is linked to lifestyle factors, suggesting prevention is possible.
• Effective, accessible preventive strategies are needed due to a lack of disease-modifying treatments.
• The Luci program is a remote, coach-supported intervention for lifestyle modification.

Purpose of the Study:

• To determine if the 24-week Luci program reduces dementia behavioral risk.
• To assess Luci's efficacy in improving lifestyle habits (diet, physical activity, cognitive engagement).

Main Methods:

• A 52-week, two-arm, randomized, single-blind, parallel-group study.
• 370 cognitively healthy adults (aged 50-75) at risk in at least one lifestyle domain.
• Comparison between the Luci intervention and a Waitlist control group, with outcomes measured at weeks 12, 24, and 52.

Main Results:

• The primary endpoint is the proportion of participants with clinically significant lifestyle changes at week 24.
• Hypothesis: Luci group will show a higher proportion of participants achieving lifestyle changes compared to the Waitlist group.
• Analysis includes logistic regression, linear mixed models, and structural equation modeling.

Conclusions:

• Digital interventions like Luci offer advantages such as reduced barriers, convenience, and lower costs.
• Validated digital programs have potential for large-scale dementia prevention.
• Luci could mitigate the public health burden of dementia.