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Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
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Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
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Public Health.

Marta Milà-Alomà1, Zachary Hausle1, Kellen K Petersen2

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This summary is machine-generated.

Later amyloid positivity is linked to earlier tau positivity, with differences observed based on sex and APOEε4 status. These factors influence Alzheimer's disease progression and clinical trial strategies.

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Area of Science:

  • Neurodegenerative diseases
  • Alzheimer's disease (AD) research
  • Biomarker discovery

Background:

  • Alzheimer's disease (AD) is characterized by amyloid and tau accumulation.
  • The interplay between these pathologies and other factors like sex and APOEε4 is not fully understood.

Purpose of the Study:

  • To examine temporal relationships between amyloid and tau positivity using PET imaging.
  • To investigate the modifying effects of sex and APOEε4 on these temporal relationships.

Main Methods:

  • Utilized longitudinal amyloid and tau PET imaging data from 757 ADNI participants.
  • Estimated age at amyloid or tau positivity and the amyloid-tau interval.
  • Employed linear regression models to assess the influence of sex and APOEε4 status.

Main Results:

  • Men and APOEε4 non-carriers showed a later age at amyloid and tau positivity.
  • APOEε4 status, not sex, modified the association between amyloid and tau positivity ages.
  • Most individuals became amyloid positive before tau positive; men had a longer amyloid-tau interval than women.

Conclusions:

  • Later age at amyloid positivity correlates with earlier tau positivity, influenced by sex and APOEε4 status.
  • Findings suggest variations in tau-related disease progression.
  • Emphasizes the importance of considering sex and APOEε4 in AD clinical trials targeting tau pathology.