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Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
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Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
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Public Health.

Han Kyu Na1, Han-Kyeol Kim2, Elena Tsoy3,4

  • 1Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of (South).

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|December 23, 2025
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Summary
This summary is machine-generated.

Social Determinants of Health (SDOH) significantly impact Alzheimer's disease (AD) progression. Lower SDOH accelerates tau and amyloid accumulation, worsening cognitive decline in individuals with and without amyloid plaques.

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Area of Science:

  • Neuroscience
  • Public Health
  • Gerontology

Background:

  • Social Determinants of Health (SDOH), such as education and socioeconomic status, are recognized influences on cognitive health and dementia risk in older adults.
  • The precise mechanisms linking SDOH to brain health, especially Alzheimer's disease (AD) biomarkers, remain incompletely understood.
  • This research investigated the influence of socioeconomic disparities on the longitudinal progression of AD biomarkers.

Purpose of the Study:

  • To explore the impact of socioeconomic disparities on the progression of Alzheimer's disease (AD) biomarkers over time.
  • To analyze how varying levels of SDOH affect the accumulation of amyloid and tau proteins and cognitive decline.
  • To investigate differences in biomarker progression between individuals with and without baseline amyloid positivity.

Main Methods:

  • A retrospective study involving 185 participants (77 healthy, 75 MCI, 33 dementia) with longitudinal AD biomarker (ATN) evaluation.
  • Utilized dual PET imaging (18F-Florbetaben, 18F-Flortaucipir), MRI, and neuropsychological assessments.
  • Participants were stratified into low, middle, and high SDOH groups based on education, income, residential area, and vascular risk factors; linear mixed models analyzed biomarker changes and cognitive performance.

Main Results:

  • No significant cross-sectional differences in amyloid or tau burden were observed across SDOH groups.
  • Among amyloid-positive individuals, the low SDOH group showed significantly faster tau accumulation and cognitive decline (language, visuospatial).
  • Among amyloid-negative individuals, the low SDOH group exhibited faster amyloid accumulation and greater language decline compared to the high SDOH group.

Conclusions:

  • Disadvantaged SDOH are linked to accelerated Alzheimer's disease progression, evidenced by faster tau accumulation in amyloid-positive individuals and quicker amyloid buildup in amyloid-negative individuals.
  • These findings underscore the critical role of SDOH in AD pathogenesis and progression.
  • Incorporating SDOH into clinical trials and developing targeted interventions for low SDOH populations are crucial for mitigating AD progression.