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Updated: Jan 8, 2026
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Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
Published on: August 22, 2012
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Public Health
Shanshan Wang1, Uyen-Sa Nguyen1, Zhengyang Zhou1
1University of North Texas Health Science Center, Fort Worth, TX, USA.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
Summary
Social determinants of health (SDOH) are linked to cognitive decline, including mild cognitive impairment (MCI) and dementia. These associations differ significantly across racial and ethnic groups, highlighting the need for tailored interventions.
Area of Science:
- Neuroscience
- Public Health
- Sociology
Background:
- Social determinants of health (SDOH) significantly impact health outcomes.
- Cognitive impairment, including mild cognitive impairment (MCI) and dementia, is a growing public health concern.
- Racial and ethnic disparities exist in cognitive health and exposure to SDOH.
Purpose of the Study:
- To investigate the relationship between various social determinants of health (SDOH) and cognitive impairment (MCI and dementia).
- To determine if these associations differ among Hispanic, non-Hispanic Black, and non-Hispanic White populations.
Main Methods:
- Utilized data from the Health & Aging Brain Study-Health Disparities (HABS-HD) with 3229 participants.
- Defined five dimensions of SDOH disadvantages: economic, education, healthcare access, neighborhood, and social.
- Employed multinomial logistic regression, controlling for age, sex, and APOE4 status.
Main Results:
- All five dimensions of SDOH disadvantages were associated with increased odds of dementia and MCI.
- Associations between SDOH disadvantages and dementia were stronger in non-Hispanic Black individuals.
- Four SDOH disadvantages showed stronger associations with MCI in non-Hispanic White individuals.
- A dose-response relationship was observed between the number of SDOH disadvantages and cognitive impairment.
Conclusions:
- A wide spectrum of SDOH is associated with cognitive impairment.
- The strength of SDOH associations with cognitive impairment varies across racial/ethnic groups.
- Tailored strategies are necessary to address SDOH and mitigate cognitive health disparities.
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