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Published on: August 22, 2012
Public Health
Shanshan Wang1, Uyen-Sa Nguyen1, Zhengyang Zhou1
1University of North Texas Health Science Center, Fort Worth, TX, USA.
Social determinants of health (SDOH) disadvantages are linked to lower cognitive performance in unimpaired individuals. These associations are particularly strong among Hispanic participants, suggesting targeted intervention opportunities.
Area of Science:
- Neuroscience
- Public Health
- Sociology
Background:
- Social determinants of health (SDOH) significantly impact health outcomes.
- Understanding SDOH's effect on cognitive function is crucial for aging populations.
- Disparities in SDOH may contribute to cognitive decline across racial/ethnic groups.
Purpose of the Study:
- To investigate the association between multidimensional SDOH disadvantages and cognitive performance in cognitively unimpaired individuals.
- To determine if these associations differ across racial/ethnic groups.
Main Methods:
- Utilized data from 2294 cognitively unimpaired participants in the Health & Aging Brain Study-Health Disparities (HABS-HD) study.
- Defined multidimensional SDOH disadvantages using 16 indicators across economic, educational, healthcare access, neighborhood, and social domains.
- Assessed cognitive performance using the Mini-Mental State Examination (MMSE) and analyzed associations using linear regression, adjusting for age, sex, and APOE4 status.
Main Results:
- Multidimensional SDOH disadvantages were associated with lower MMSE scores in cognitively unimpaired individuals.
- Associations between social disadvantage and cognition were not significant when stratified by race/ethnicity.
- Economic, educational, neighborhood, and healthcare access disadvantages showed stronger associations with cognitive performance among Hispanic participants, indicating dose-response relationships.
Conclusions:
- The impact of SDOH disadvantages on cognitive performance varies significantly among racial/ethnic groups.
- Hispanic individuals exhibit stronger associations between SDOH disadvantages and cognitive decline, highlighting this group for potential early intervention and prevention strategies.
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