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Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
Published on: August 22, 2012
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Public Health
1Florida State University, Tallahassee, FL, USA.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
Summary
COVID-19 vaccine effectiveness wanes significantly over time for individuals with Alzheimer's disease and related dementias (ADRD) and mild cognitive impairment (MCI). Booster shots are crucial for maintaining protection in these vulnerable populations.
Area of Science:
- Immunology and Infectious Diseases
- Neuroscience and Neurology
- Public Health and Epidemiology
Background:
- Individuals with Alzheimer's disease and related dementias (ADRD) and mild cognitive impairment (MCI) are at higher risk for severe COVID-19 outcomes.
- Challenges in preventive measure adherence and chronic condition management further increase risks for ADRD/MCI populations.
- Waning vaccine effectiveness over time necessitates ongoing strategies to maintain protection against SARS-CoV-2.
Purpose of the Study:
- To assess COVID-19 vaccine effectiveness and duration of immunity in individuals with ADRD/MCI.
- To identify demographic and clinical factors influencing vaccine effectiveness in this vulnerable group.
- To inform public health strategies for optimizing protection in individuals with ADRD/MCI.
Main Methods:
- Retrospective cross-sectional study using data from the All of Us Researcher Workbench (December 2020 - July 2022).
- Extracted demographic, social determinants of health, and electronic health record (EHR) data, including COVID-19 vaccination details.
- Assessed vaccine effectiveness by analyzing the time from the second vaccine dose to reported SARS-CoV-2 infections.
Main Results:
- Lower full vaccination rates were observed in Black and African American individuals with ADRD/MCI compared to non-Hispanic Whites.
- Vaccine effectiveness in individuals with ADRD/MCI decreased significantly from 96.7% at 2 weeks to 76.4% at 6 months and 54.2% at 1.5 years post-vaccination.
- Greater waning of vaccine effectiveness was noted in older adults (over 65) and those with multiple chronic conditions.
Conclusions:
- Chronic conditions, particularly ADRD/MCI, influence COVID-19 vaccine effectiveness, highlighting the need for tailored strategies.
- Promoting timely vaccination boosters is essential to maintain protection against currently circulating SARS-CoV-2 variants in vulnerable populations.
- Public health initiatives should focus on increasing booster uptake among individuals with ADRD/MCI for equitable and effective COVID-19 prevention.
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