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Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
Published on: August 22, 2012
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Public Health
Hui Shi1, Loren Lipworth2, Qian Xiao3
1Vanderbilt Memory and Alzheimer's Center, Nashville, TN, USA.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
Summary
Maintaining consistent short or long sleep durations over time increases Alzheimer's Disease and Related Dementias (ADRD) risk. Changes in sleep patterns may also signal heightened ADRD risk, emphasizing healthy sleep for prevention.
Area of Science:
- Gerontology and Sleep Science
- Neurodegenerative Disease Epidemiology
Background:
- Both short (<7 hours) and long (>9 hours) sleep durations are linked to increased Alzheimer's Disease and Related Dementias (ADRD) risk.
- Limited research has explored how long-term sleep duration *trajectories* influence ADRD risk.
- This study investigates sleep duration patterns over time and their association with ADRD in a diverse cohort.
Purpose of the Study:
- To examine long-term sleep duration trajectories and their association with incident Alzheimer's Disease and Related Dementias (ADRD) risk.
- To identify specific sleep patterns (e.g., consistently short, long, or changing durations) linked to increased ADRD incidence.
Main Methods:
- Utilized data from the Southern Community Cohort Study (SCCS) including 17,945 participants aged 65+ enrolled in Medicare.
- Defined sleep duration trajectories based on self-reported sleep (<7, 7-9, >9 hours) over a 4.5-year period.
- Employed adjusted Cox proportional hazards regression to analyze the association between sleep trajectories and incident ADRD identified via Medicare claims.
Main Results:
- Suboptimal sleep duration trajectories were associated with a 20%-69% increased risk of ADRD compared to maintaining healthy sleep (7-9 hours).
- The 'long-short' sleep trajectory showed the highest cumulative ADRD incidence (HR=1.69).
- Consistently short (short-short, HR=1.20) and long (long-long, HR=1.56) sleep durations, as well as transitions (long-healthy, short-long), were linked to higher ADRD risk.
Conclusions:
- Maintaining either short or long sleep duration over time is associated with elevated incident ADRD risk.
- Changes in sleep duration (e.g., transitioning from long to short sleep) may also be a significant risk factor for ADRD.
- Promoting consistent, healthy sleep durations (7-9 hours) throughout midlife is crucial for reducing the risk of developing ADRD.
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