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Updated: Jan 8, 2026
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Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
Published on: August 22, 2012
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Public Health
Francesca R Dino1, Danelle J Carter1, Reilly Costello2
1University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
Summary
Environmental and occupational exposures in childhood and adulthood are linked to increased Lewy body dementia (LBD) risk. Identifying sex-specific factors is crucial for understanding LBD and developing targeted prevention strategies.
Area of Science:
- Neurodegenerative diseases
- Environmental health
- Occupational health
Background:
- Lewy body dementia (LBD) exhibits sex-based risk disparities, with males at higher risk than females.
- Environmental and occupational exposures, varying by sex, may influence LBD risk.
- Limited research exists on LBD risk factors compared to Alzheimer's and Parkinson's diseases.
Purpose of the Study:
- To investigate environmental and occupational risk factors for Lewy body dementia (LBD).
- To identify sex-specific differences in LBD risk factors.
- To explore the impact of exposures from childhood through adulthood on LBD development.
Main Methods:
- A remote cross-sectional survey (LBD-TOROS) included 130 LBD patients and 124 controls.
- Data collected on childhood and adult environmental/occupational exposures, lifestyle, and demographics.
- Statistical analyses (Chi square, Mann-Whitney U, logistic regression) were performed on the overall and sex-stratified cohorts.
Main Results:
- Individuals with LBD reported lower education, income, and social status.
- Increased LBD risk was associated with childhood/adulthood exposure to metal dust/fumes, glue/adhesive, welding, soldering, and smoking.
- Sex-specific factors included decaffeinated coffee and pesticides for females, and private well water and green tea for males.
Conclusions:
- Environmental and occupational exposures during both childhood and adulthood significantly elevate LBD risk.
- Sex-specific risk factors offer insights into LBD pathogenesis and inform prevention strategies.
- Further research is needed on LBD in females due to current literature bias towards male participants.
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