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Public Health
Eva Glaeser1, Ingo Kilimann2, Moritz Platen3
1German Center for Neurodegenerative Diseases, Greifswald, Mecklenburg-West Pomerania, Germany.
Cognitive decline, including subjective cognitive decline (SCD), mild cognitive impairment (MCI), and Alzheimer's Disease (AD), significantly increases healthcare costs. Early interventions are crucial to manage the economic burden associated with these conditions.
Area of Science:
- Neuroscience
- Health Economics
Background:
- Assesses healthcare costs and associated factors in patients with subjective cognitive decline (SCD), mild cognitive impairment (MCI), and Alzheimer's Disease (AD) dementia.
- Compares these costs to those of healthy controls.
Purpose of the Study:
- To evaluate the economic burden of cognitive decline at various stages.
- To identify factors influencing healthcare costs in these patient groups.
Main Methods:
- Utilized data from the DELCODE study, including clinical information, risk factors, and healthcare resource utilization.
- Calculated costs from both payer and societal perspectives.
- Employed multivariate regression analyses to determine cost-associated factors.
Main Results:
- Societal costs were significantly higher for SCD (50% increase), MCI (199% increase), and AD (602% increase) compared to controls.
- ApoE ε4 negative status and hypertension were linked to increased costs.
- Lower education and high cholesterol were associated with reduced costs.
Conclusions:
- Healthcare costs are substantially elevated even in early stages of cognitive impairment (SCD and MCI).
- Formal and informal care significantly contribute to the economic burden.
- Early interventions are vital for reducing economic impact and potentially delaying disease progression.
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