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Related Concept Videos

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Primary Healthcare Services

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Primary care promotes wellness and prevents disease. This care includes health promotion, education, protection (such as immunizations), early disease screening, and environmental considerations. Settings providing this type of healthcare include physician offices, public health clinics, school nursing, and community health nursing.
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Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
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Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
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Healthcare Agencies II01:17

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Public Health.

Sinthujah Vigneswaran1,2,3, Everard G B Vijverberg1, Frederik Barkhof4

  • 1Alzheimer Center, Department of Neurology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, Netherlands.

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|December 23, 2025
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Summary
This summary is machine-generated.

Only 6% of all patients and 15% with mild cognitive impairment or Alzheimer's disease met eligibility for anti-amyloid therapies (AAT). This study assessed AAT eligibility in a memory clinic, providing crucial data for healthcare system preparedness and cost analyses.

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Area of Science:

  • Neurology
  • Pharmacology
  • Biomarkers

Background:

  • Recent approvals of anti-amyloid therapies (AAT) for Alzheimer's disease (AD) necessitate patient eligibility assessments.
  • Real-world data on AAT eligibility, estimated at 1-18% based on biomarkers, remain limited.
  • This study evaluated AAT eligibility in a tertiary memory clinic using lecanemab criteria (2020-2022).

Purpose of the Study:

  • To determine the proportion of patients in a tertiary memory clinic eligible for anti-amyloid therapies (AAT).
  • To assess eligibility based on established criteria for Alzheimer's disease (AD) and mild cognitive impairment (MCI).
  • To provide data for healthcare system preparedness and budget-impact analyses of AAT.

Main Methods:

  • 1309 patients from Alzheimer Center Amsterdam (2020-2022) underwent standard diagnostic workup.
  • Eligibility criteria included clinical diagnosis of MCI/AD, CDR 0.5-1.0, MMSE 22-27, amyloid positivity, and <4 microbleeds.
  • Exclusion criteria involved APOE ε4/ε4 homozygosity and anticoagulant use.

Main Results:

  • Of 1309 patients, 514 had MCI or AD; 196 met CDR/MMSE criteria.
  • 158 were amyloid-positive, 25 had unknown status; 108 met biomarker criteria (8% of all-comers).
  • After exclusions, 79 patients (6% of all-comers, 15% of MCI/AD) were eligible for AAT.

Conclusions:

  • In a tertiary memory clinic, 8% of all patients and 21% with MCI/AD met criteria for AAT.
  • Findings are crucial for healthcare system planning and economic evaluations of AAT.
  • This study provides real-world data on AAT eligibility in a clinical setting.