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Public Health.
Oshadi M Jayakody1, Ying Jin1, Cuiling Wang2
1Albert Einstein College of Medicine, Bronx, NY, USA.
Older adults who are "super movers" with fast gait speeds have a lower risk of cognitive impairment and slower cognitive decline. This novel aging phenotype may offer insights into protective mechanisms against dementia.
Area of Science:
- Gerontology
- Neuroscience
- Public Health
Background:
- Slow gait speed is a known predictor of cognitive decline and dementia.
- The cognitive implications of exceptionally fast gait speeds in older adults remain underexplored.
Purpose of the Study:
- To investigate the association between a
Main Methods:
- Utilized data from five Health and Retirement Study International Network of Studies (HRS-INS) to assess cognitive impairment risk.
- Employed meta-analysis of Cox proportional hazards models to pool risk estimates for incident cognitive impairment.
- Analyzed cognitive decline rates in the LonGenity study using linear mixed-effects models.
Main Results:
- Super movers demonstrated significantly lower risks of cognitive impairment across multiple HRS-INS studies.
- Meta-analysis of 3,999 participants (358 super movers) revealed a 51% lower risk of cognitive impairment (HR 0.49).
- In the LonGenity study, super movers exhibited slower cognitive decline in global cognition and specific neuropsychological tests.
Conclusions:
- The
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