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Infection01:20

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
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Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
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Basic Science and Pathogenesis.

Jessica S Britton1, Jesse C Wiley1, Jaclyn Beck1

  • 1Sage Bionetworks, Seattle, WA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
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Summary
This summary is machine-generated.

Agora provides Alzheimer's disease (AD) researchers with open access to target-based evidence, accelerating therapeutic discovery through data sharing and interactive tools. This platform facilitates collaboration between academia and industry to advance potential AD therapeutics.

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Area of Science:

  • Neuroscience
  • Genomics
  • Drug Discovery

Background:

  • Agora is an open-access web application providing Alzheimer's disease (AD) researchers access to target-based evidence.
  • It leverages the National Institute on Aging's (NIA) translational research portfolio to accelerate AD research and therapeutic discovery.
  • The platform utilizes interactive tools, data visualizations, and summarized evidence for broad researcher accessibility.

Purpose of the Study:

  • To facilitate the sharing of information on potential AD therapeutic targets.
  • To enable researchers to evaluate and compare complex multi-omic data.
  • To accelerate the investigation of promising new AD therapeutic targets, pathways, and mechanisms.

Main Methods:

  • Agora aggregates summary evidence and displays results from targeted validation studies.
  • It allows users to browse over 950 potential therapeutic targets nominated by NIA's AMP-AD and TREAT-AD centers.
  • The platform offers harmonized genome-wide analyses of human transcriptomic, proteomic, and metabolomic data with interactive tools for non-bioinformaticians.

Main Results:

  • Agora presents accessible information and results on AD targets for a wide range of researchers.
  • Recent updates include new TREAT-AD target nominations.
  • Enhanced connections to external resources, including a drug development section and UniprotKB integration, have been implemented.

Conclusions:

  • Advancing AD therapeutics requires collaborative efforts across academia and industry.
  • Agora unites the AD research community by enabling the development and sharing of target hypotheses.
  • This facilitates accelerated investigation of novel AD therapeutic targets, pathways, and mechanisms.