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Basic Science and Pathogenesis.

Garima Sharma1, Monika Kadian1, Anushka Vashishth1

  • 1University institute of pharmaceutical sciences, Panjab University, Chandigarh, Chandigarh, India.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
PubMed
Summary
This summary is machine-generated.

Flufenamic acid shows neuroprotective effects against depression-like behaviors in mice. This study highlights its potential to combat neuroinflammation and oxidative stress, offering a novel therapeutic avenue for major depressive disorder.

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Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Neuroinflammation is increasingly recognized as a key factor in major depressive disorder.
  • Oxidative stress activates the NLRP3 inflammasome, contributing to depression pathogenesis.

Purpose of the Study:

  • To investigate the therapeutic effects of flufenamic acid on an experimental model of depression-like behavior.
  • To assess flufenamic acid's impact on neuroinflammation and oxidative stress markers.

Main Methods:

  • Male BALB/c mice were subjected to chronic forced swim stress.
  • Treatment involved flufenamic acid (10 and 20 mg/kg) and fluoxetine.
  • Evaluated behavioral tests, oxidative stress markers, antioxidant levels, mitochondrial enzyme activity, corticosterone, and monoamine levels.

Main Results:

  • Flufenamic acid significantly reduced depression-like behaviors, including immobility time and sucrose preference.
  • It restored antioxidant enzyme levels and modulated oxidative stress in the brain.
  • The treatment normalized corticosterone levels, monoamine balance, and reduced histopathological damage.

Conclusions:

  • Flufenamic acid demonstrates significant neuroprotective potential in an experimental depression model.
  • Its efficacy suggests a role in mitigating neuroinflammation and oxidative stress associated with depression.