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Basic Science and Pathogenesis
João Vitor Bittencourt Venera1
1UNIFEBE, Balneário Camboriú, Santa Catarina, Brazil.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
Summary
Immersive virtual reality (iVR) shows promise for assessing Alzheimer's disease (AD) and mild cognitive impairment (MCI), detecting early AD signs. However, its effectiveness in cognitive training for AD patients requires further research through randomized controlled trials.
Area of Science:
- Neuroscience
- Gerontology
- Rehabilitation Technology
Background:
- Alzheimer's disease (AD) causes progressive cognitive decline, with limited success from traditional treatments.
- Immersive virtual reality (iVR) presents novel opportunities for cognitive assessment and rehabilitation in AD patients.
- iVR's interactive environments can be customized for therapeutic interventions to potentially improve cognitive functions and quality of life.
Purpose of the Study:
- To systematically review the use of iVR in assessing and treating individuals with AD or mild cognitive impairment (MCI).
- To evaluate the acceptability, feasibility, and efficacy of iVR interventions.
- To explore the correlation of iVR with neuroanatomical substrates and existing screening methods.
Main Methods:
- A systematic review of studies utilizing iVR for AD/MCI assessment and treatment.
- Searched databases: Medline, PsycINFO, Embase, CINAHL, and Web of Science.
- Focused on iVR's acceptability, feasibility, efficacy, and correlation with neuroanatomy and screening.
Main Results:
- Nine studies met inclusion criteria; participants tolerated iVR well.
- One study showed iVR could detect prodromal AD, correlating with neuroanatomical changes.
- iVR differentiated AD patients from controls in two studies, but lacked robust controls; cognitive training showed positive feedback but inconsistent benefits.
Conclusions:
- iVR is a promising tool for assessing older adults and AD patients, especially when integrated with neurodegeneration models and screening methods.
- The therapeutic efficacy of iVR for cognitive training in AD remains inconclusive.
- Further randomized controlled trials are needed to validate iVR's effectiveness in AD assessment and cognitive rehabilitation.
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