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Related Concept Videos

Primary Healthcare Services01:30

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Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
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Related Experiment Video

Updated: Jan 8, 2026

Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
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Public Health.

Ellen Riquelme Sepúlveda1, Liset Gonzalez2, Claudia Duran-Aniotz3

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Summary
This summary is machine-generated.

Environmental and lifestyle factors in Latin America influence biological aging. Exposures like socioeconomic adversity, diet, pollution, and behaviors impact telomere length (TL) and epigenetic clocks, affecting health risks.

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Area of Science:

  • Environmental Health
  • Genetics
  • Epidemiology

Background:

  • Aging is a significant risk factor for numerous human diseases.
  • Genetic and epigenetic biomarkers, including telomere length (TL) and epigenetic clocks, are crucial for assessing biological aging and disease risk.
  • The exposome, encompassing socioeconomic factors, lifestyle, pollution, and early life experiences, accelerates biological aging, with limited research in Latin America.

Purpose of the Study:

  • To systematically review the evidence on the relationship between various exposome factors and TL or epigenetic clock biomarkers in the Latin American population.
  • To address the research gap concerning the exposome's impact on biological aging in a region with a high burden of health risk factors.

Main Methods:

  • Conducted a systematic literature search following PRISMA guidelines across PubMed, Scopus, and SciELO.
  • Keywords included social determinants of health, lifestyle behaviors, pollution, early life experiences, and specific Latin American countries, alongside telomere length and epigenetic clocks.

Main Results:

  • Fourteen observational studies from eight Latin American countries were analyzed.
  • Epigenetic clocks showed accelerated aging with adequate sleep and late bedtimes; short sleep and sedentary behavior in females indicated age deceleration.
  • Telomere length (TL) was associated with food insecurity, lower education, childhood deprivation, and smoking (shorter TL), while fruit/vegetable-rich diets, childhood poverty/violence, and arsenic exposure were linked to longer TL. PM2.5 exposure during pregnancy correlated with shorter TL.

Conclusions:

  • This review provides the first comprehensive summary of exposome impacts on TL and epigenetic clocks in Latin America.
  • Socioeconomic adversity, dietary patterns, pollution, and lifestyle behaviors are identified as significant factors influencing biological aging in this population.