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Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
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Public Health.

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  • 1Celia Scott Weatherhead Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.

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Summary
This summary is machine-generated.

High variability in vascular risk factors (VRFs) like blood pressure and glucose from childhood to midlife is linked to poorer midlife cognitive function. Managing VRF variability may support cognitive health.

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Area of Science:

  • Neuroscience
  • Public Health
  • Cardiology

Background:

  • Vascular risk factors (VRFs) variability, not just mean levels, is linked to dementia risk.
  • The impact of long-term variability in multiple VRFs on midlife cognitive function (CF) remains unclear.

Purpose of the Study:

  • To investigate the composite and relative impact of VRF variability from childhood to adulthood on midlife CF.
  • To assess how variability in systolic blood pressure (SBP), fasting plasma glucose (FPG), non-high density lipoprotein cholesterol (non-HDL), and body mass index (BMI) affects cognitive performance.

Main Methods:

  • Utilized data from the Bogalusa Heart Study with at least 3 VRF measurements from childhood to midlife.
  • Calculated long-term VRF variability (VRFV) using the coefficient of variation (CV).
  • Developed a weighted composite score of variability (WCS) and assessed midlife CF via a global cognitive score (GCS) and cluster analysis of neuropsychological (NP) tests.

Main Results:

  • Highest variability in SBP and FPG showed the greatest negative impact on midlife CF.
  • Higher WCS was associated with decreased GCS and increased odds of suboptimal cognitive profiles.
  • Specifically, the highest WCS tertile correlated with a 0.1 GCS decrease and 77% higher odds of mixed-low cognitive function.

Conclusions:

  • Variability in VRFs throughout the life course significantly impacts midlife cognitive function.
  • Targeting VRF variability from childhood onwards may be a crucial strategy for preserving cognitive health.