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Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
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Public Health.

Jennifer E Bramen1,2,3, Prabha Siddarth3,4, Emily S Popa3

  • 1University of California Los Angeles, Los Angeles, CA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
PubMed
Summary
This summary is machine-generated.

A lifestyle intervention improved brain blood flow and diabetic risk in Alzheimer's disease (AD) patients. Higher adherence to the multi-domain program, including diet and exercise, correlated with better outcomes.

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Area of Science:

  • Neurology
  • Gerontology
  • Cardiovascular Science

Background:

  • Alzheimer's disease (AD) management requires medical and lifestyle interventions.
  • Reduced cerebral blood flow (CBF) is a hallmark of AD, influenced by modifiable risk factors.

Purpose of the Study:

  • To investigate the impact of a multi-domain lifestyle intervention on diabetic risk and CBF in AD patients.
  • To assess the effects of intervention adherence on these outcomes.

Main Methods:

  • A randomized clinical trial involving 48 participants with amyloidosis.
  • The active group received coaching, exercise, and supplementation alongside medical management; the control group received standard care.
  • Cerebral blood flow (CBF) was measured using ASL MRI, and diabetic risk was assessed using QUICKI. Adherence was measured via the clinician rating scale (CRS).

Main Results:

  • The active intervention group showed significantly improved post-trial CBF in key brain regions compared to the control group.
  • Higher adherence to the intervention was associated with greater improvements in regional CBF and QUICKI scores.
  • No significant demographic differences were observed between treatment arms at baseline.

Conclusions:

  • A multi-domain intervention combining medical management, exercise, and a carbohydrate-restricted diet shows promise for improving diabetic risk and CBF in AD patients.
  • Adherence to lifestyle interventions is a critical factor in achieving positive outcomes for Alzheimer's disease patients.