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Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
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Public Health.

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Summary
This summary is machine-generated.

Structural arterial stiffness, not load-dependent stiffness, is linked to lower cognitive function and brain abnormalities. Interventions for arterial stiffness may preserve cognition and brain health.

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Area of Science:

  • Cardiovascular Health
  • Neurology
  • Aging Research

Background:

  • Recent advancements enable differentiation of load-dependent (LD-PWV) and structural (S-PWV) arterial stiffness from total pulse-wave velocity (T-PWV).
  • Arterial stiffness is an emerging risk factor for Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD).
  • Prior research suggests S-PWV, but not LD-PWV, may correlate with cognitive decline and AD biomarkers.

Purpose of the Study:

  • To test the hypothesis that higher S-PWV, not LD-PWV, is associated with lower cognitive function.
  • To investigate the relationship between S-PWV and LD-PWV with MRI imaging biomarkers.
  • To examine the association of arterial stiffness measures with plasma and PET AD biomarkers.

Main Methods:

  • Carotid-femoral pulse-wave velocity (PWV) was measured in 516 participants (mean age 70.4 years).
  • S-PWV and LD-PWV were calculated using participant-specific models.
  • Cognitive function, brain MRI, and AD biomarkers (plasma and PET) were assessed.

Main Results:

  • Higher T-PWV and S-PWV correlated with lower global cognitive function.
  • Higher LD-PWV was linked to reduced white matter integrity and cerebral blood flow.
  • Higher T-PWV and S-PWV were associated with increased gray matter free water and white matter abnormalities.

Conclusions:

  • Structural arterial stiffness is associated with cognitive impairment and brain structural abnormalities.
  • Arterial stiffness related to blood pressure affects white matter integrity and blood flow.
  • Targeting arterial stiffness may be a strategy to maintain cognitive and cerebrovascular health.