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Public Health.

Jiafeng Wang1,2, Xiaoyu Wang3, Qianqian Xie3

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Summary
This summary is machine-generated.

Choroid plexus (ChP) volume shows an inverted U-shaped link to cognitive decline in older adults, particularly in men and those under 70. This association is partly explained by ventricular and medial temporal lobe atrophy.

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Area of Science:

  • Neuroimaging
  • Gerontology
  • Cerebrospinal Fluid Dynamics

Background:

  • The choroid plexus (ChP) produces cerebrospinal fluid (CSF) and forms the blood-CSF barrier.
  • Its role in cognitive decline in aging populations requires further investigation.

Purpose of the Study:

  • To examine the longitudinal association between choroid plexus (ChP) volume and cognitive decline in older adults.
  • To explore potential mediating factors in this relationship.

Main Methods:

  • A population-based cohort study of 176 dementia-free older adults (≥60 years).
  • Magnetic resonance imaging (MRI) for choroid plexus (ChP) volume segmentation.
  • Mini-Mental State Examination (MMSE) for cognitive assessment over time (2014, 2018, 2021).
  • Statistical analysis using linear mixed-effects and mediation models.

Main Results:

  • An inverted U-shaped relationship was observed between choroid plexus (ChP) volume and cognitive decline (MMSE score decline).
  • This association was more pronounced in men and individuals aged 70 years and older.
  • Inferior lateral ventricular (ILV) volume and quantitative medial temporal lobe atrophy (QMTA) partially mediated the link between higher ChP volume and cognitive decline.

Conclusions:

  • Choroid plexus (ChP) volume exhibits an inverted U-shaped association with global cognitive decline.
  • The relationship is significant in men and younger-old adults (<70 years).
  • Inferior lateral ventricular (ILV) volume and quantitative medial temporal lobe atrophy (QMTA) are significant mediators of this association.