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Summary
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The Impact of Intensive Treatment of Systolic Blood Pressure (IPAT) study found that hospital databases were most effective for recruitment. Many interested individuals were excluded due to systolic blood pressure (SBP) below 130 mmHg.

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Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Clinical Trials

Background:

  • The Impact of Intensive Treatment of Systolic Blood Pressure on Brain Perfusion, Amyloid, and Tau (IPAT) study investigates intensive blood pressure treatment effects.
  • This randomized controlled trial targets older adults (60-85) with hypertension (SBP > 130 mmHg).
  • It aims to assess impacts on brain amyloid and tau using positron emission tomography (PET).

Purpose of the Study:

  • To evaluate the effectiveness of IPAT study recruitment strategies.
  • To identify primary reasons for participant exclusion during enrollment.
  • To optimize future recruitment for clinical trials involving hypertension.

Main Methods:

  • Recruitment utilized hospital databases (MyChart), marketing emails, and community outreach events.
  • 1735 individuals were phone screened and 140 consented over two years (Oct 2022 - Nov 2024).
  • Exclusion criteria primarily involved systolic blood pressure (SBP) < 130 mmHg and inability to undergo MRI/PET scans.

Main Results:

  • Hospital databases yielded the highest randomization rate (31%).
  • Key exclusion reasons included SBP < 130 mmHg (390 screened, 13 consented) and lack of participant interest (254 screened).
  • Consented participants were predominantly Non-Hispanic White (80%) with higher education (88%).

Conclusions:

  • Hospital databases are effective for recruiting for the IPAT study.
  • Current strategies may over-recruit individuals with well-controlled blood pressure.
  • Future recruitment should target underserved populations with limited blood pressure management access, such as minority or rural communities.