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Basic Science and Pathogenesis.

Lauren Bass1,2, Amanda Kuzma1,3, Otto Valladares1,2

  • 1Institute for Biomedical Informatics, Philadelphia, PA, USA.

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|December 23, 2025
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Summary
This summary is machine-generated.

The National Institute on Aging Genetics of Alzheimer's Disease (NIAGADS) repository provides crucial genomics data for Alzheimer's disease (AD) research. It houses extensive datasets, enabling efficient genetic studies and advancing our understanding of AD.

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Area of Science:

  • Genomics
  • Neurodegenerative Diseases
  • Alzheimer's Disease Genetics

Background:

  • NIAGADS is a national repository for genomics and sequencing data, focusing on Alzheimer's disease (AD) and related neurological disorders.
  • It collaborates with major consortia like ADGC, CHARGE, ADSP, and GCAD to manage large AD datasets.
  • These collaborations facilitate community access and utilization of extensive AD genetic information.

Purpose of the Study:

  • To provide a centralized platform for accessing and sharing genomic data relevant to Alzheimer's disease research.
  • To support qualified investigators in their studies of the genetic underpinnings of AD and related neurological conditions.
  • To facilitate the deposition and dissemination of NIA-funded AD genetics study data.

Main Methods:

  • NIAGADS manages a Data Sharing Service (DSS) for depositing and sharing genomic data and association results.
  • Researchers can access the NIAGADS Alzheimer's Genomics Database for annotation resources.
  • Data deposition is mandated for NIA-funded AD genetics studies.

Main Results:

  • As of January 2025, NIAGADS hosts 130 datasets with over 237,000 samples, including array, sequencing, and gene expression data.
  • Whole exome sequencing (WES) has been completed for 20,499 samples and whole genome sequencing (WGS) for 58,507 samples.
  • Additional sequencing data from approximately 15,000 genomes will be released in 2026.

Conclusions:

  • NIAGADS serves as a vital resource for advancing Alzheimer's disease genetics research.
  • By consolidating diverse datasets, NIAGADS enhances research efficiency for the scientific community.
  • Comprehensive datasets, guidelines, and features are accessible via the NIAGADS website.