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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
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Basic Science and Pathogenesis.

Michael J Borrie1,2,3,4,5, Natalie A Phillips6, Sarah Best2

  • 1Division of Geriatric Medicine, Western University, London, ON, Canada.

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Summary
This summary is machine-generated.

The Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS-ND) study enrolled diverse participants across the full neurodegeneration spectrum. This research provides valuable data on cognitive impairment and dementia for registered researchers globally.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Biomarker Research

Background:

  • The Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS-ND) study enrolled 1173 participants across 11 diagnostic cohorts, covering the full spectrum of cognitive function from normal cognition to all types of dementia.
  • Participants underwent comprehensive assessments including clinical evaluations, neuropsychology, sensory and motor tests, magnetic resonance imaging (MRI), and provided biosamples for biomarker analysis.

Purpose of the Study:

  • To fill a critical knowledge gap by recruiting a diverse participant pool representing the entire spectrum of neurodegeneration.
  • To distinguish COMPASS-ND from other large-scale studies through its inclusive recruitment strategy.

Main Methods:

  • Recruitment utilized advertising and specialty clinics for neurocognitive disorders and memory impairment.
  • Data underwent robust monitoring and cleaning for baseline and Time 2 assessments.
  • Analyses included genetic, MRI, cerebrospinal fluid (CSF), and blood biomarkers.

Main Results:

  • Data releases include baseline data, neuroimaging analyses, CSF, genetic, and blood biomarkers, accessible via the Longitudinal Online Research and Imaging System (LORIS).
  • 40 autopsies have been completed, and 119 data access requests have been submitted.
  • Ongoing Phase III recruitment aims to enroll 400 diverse participants, focusing on those without cognitive impairment or with mild cognitive impairment but not dementia, with consideration for sex/gender balance.

Conclusions:

  • COMPASS-ND successfully recruited participants across the full spectrum of neurodegeneration, addressing a gap in current research.
  • Challenges and strategies for engagement and research site funding will be discussed.
  • Data are accessible to registered researchers and trainees worldwide through data access requests.