Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Microbial Biosensors

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Matrix Stiffness Induces Endothelial Network Senescence.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same author

Wearable micromotor-based electrochemical microneedle sensors for monitoring tumor biomarkers in skin.

Biosensors & bioelectronics·2026

Same author

A Nanoconfined, Hydrogel-Partitioned LAMP Platform for Rapid, Extraction-Free Quantification of <i>Mycoplasma pneumoniae</i>.

ACS infectious diseases·2026

Same author

Thrombus-targeting nanosystems: Differential performance in arterial and venous circulation.

Journal of controlled release : official journal of the Controlled Release Society·2026

Same author

Screening and Quality Evaluation of Submerged Culture Media Formulations for <i>Pleurotus pulmonarius</i>.

Journal of fungi (Basel, Switzerland)·2026

Same author

Evaluation of <i>Corcyra cephalonica</i> as an Alternative Host for <i>Meteorus pulchricornis</i>.

Insects·2026

Same journal

Hydrothermally fabricated chitosan-alginate polyelectrolyte complex-based hemostatic patches with shape recovery.

Biomaterials advances·2026

Same journal

A multifunctional composite film comprising a citric acid-crosslinked polysaccharide matrix loaded with nutmeg essential oil nanoemulsion: suitable for facilitating active wound healing.

Biomaterials advances·2026

Same journal

Graphene oxide functionalized with polyamidoamine dendrimer as a drug delivery system for human breast cells.

Biomaterials advances·2026

Same journal

Drug-loaded biomorphic scaffolds for tissue regeneration and targeted antitumor therapy in bone metastasis models.

Biomaterials advances·2026

Same journal

Adding beta-tricalcium phosphate ceramic to additive manufactured 3D porous Ti6Al4V scaffolds enhances osteogenic activity of human mesenchymal stromal cells in vitro.

Biomaterials advances·2026

Same journal

Calcium-enhanced COF platforms for synergistic photothermal-antibacterial therapy: Unlocking calcium-mediated membrane disruption and ion overload for bacterial and biofilm eradication in wound care and clinical nursing.

Biomaterials advances·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 13, 2026

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Published on: December 9, 2010

Microenvironment-responsive nanorobots for biomedical applications.

Wenge Lv¹, Liangcheng Gu¹, Xingyu Lin¹

¹National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China.

Biomaterials Advances

|December 23, 2025

Summary

This summary is machine-generated.

Researchers developed smart nanorobots that navigate the body using natural signals, improving drug delivery to specific sites and reducing side effects. These bioinspired nanodevices offer a new path for precision medicine.

Keywords:

Deformation Degradation Locomotion Nanorobot Pathological microenvironment

More Related Videos

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

Nanosensors to Detect Protease Activity In Vivo for Noninvasive Diagnostics

Nanosensors to Detect Protease Activity In Vivo for Noninvasive Diagnostics

Published on: July 16, 2018

Related Experiment Videos

Last Updated: May 13, 2026

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Published on: December 9, 2010

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

Nanosensors to Detect Protease Activity In Vivo for Noninvasive Diagnostics

Nanosensors to Detect Protease Activity In Vivo for Noninvasive Diagnostics

Published on: July 16, 2018

Area of Science:

Biomedical Engineering
Nanotechnology
Drug Delivery Systems

Background:

Conventional therapies suffer from poor targeting, passive diffusion, and systemic toxicity.
Immune cells use chemotaxis for targeted navigation to infection sites.
Nanorobots offer a bioinspired alternative for autonomous drug delivery.

Purpose of the Study:

To review microenvironment-responsive nanorobots for autonomous drug delivery.
To categorize nanorobots based on their response to pathological signals.
To analyze design, applications, and translational challenges of these nanorobots.

Main Methods:

Categorization of nanorobots into locomotion, degradation, and deformation classes.
Analysis of bioinspired strategies mimicking immune cell navigation.
Review of endogenous biochemical cues (pH, enzymes, ROS) for nanorobot actuation.

Main Results:

Nanorobots convert biochemical cues into directed motion and shape changes.
These nanodevices achieve deep tissue penetration and lesion-specific drug release.
Three functional classes of nanorobots demonstrate diverse response behaviors.

Conclusions:

Microenvironment-responsive nanorobots represent a significant advancement in precision therapeutics.
Bioinspired design principles enable autonomous and targeted drug delivery.
Further research and development are crucial for overcoming translational challenges and realizing clinical applications.