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Updated: Jan 8, 2026
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Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
Published on: June 14, 2020
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Basic Science and Pathogenesis.
Maria Capdevila1, Laura Guzmán2, Marina Carrasco2
1Ace Alzheimer Center Barcelona, Barcelona, Spain.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
Summary
Extracellular vesicles (EVs) from Alzheimer's disease (AD) patients
Area of Science:
- Neuroscience
- Molecular Biology
- Biochemistry
Background:
- Extracellular vesicles (EVs) are implicated in Alzheimer's disease (AD) pathogenesis, but mechanisms remain unclear.
- This study investigates the role of cerebrospinal fluid (CSF)-derived EVs from AD patients in disease propagation.
- Investigating EVs in AD is crucial for understanding disease mechanisms.
Purpose of the Study:
- To examine the role of EVs in spreading Alzheimer's disease pathology.
- To assess the impact of AD CSF EVs on cognitive function and neuroinflammation in wild-type mice.
Main Methods:
- Administered CSF EVs from AD dementia patients to C57BL/6 mice for 3 months.
- Evaluated spatial memory using Morris water maze (MWM) and Novel object recognition (NOR) tests.
- Assessed neuroinflammation, synaptic integrity, Aβ plaques, and proteomic profiles.
Main Results:
- Mice exposed to AD CSF EVs exhibited significant spatial memory deficits.
- Neuroinflammation and synaptic alterations were observed in AD EVs-exposed mice.
- Proteomic analysis revealed distinct soluble fractions in human CSF EVs and mouse plasma.
Conclusions:
- EVs may play a significant role in the dissemination of AD pathology.
- Long-term exposure to AD CSF EVs impairs cognitive function and promotes neuroinflammation.
- Further research is needed to elucidate the precise mechanisms of EV-mediated AD progression.
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