Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Infection01:20

Infection

11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

524
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
524
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

676
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
676
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Stages of Infection01:26

Stages of Infection

64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multidimensional resiliency factors and psychopathology after acute trauma: Results from a prospective cohort study.

Psychological trauma : theory, research, practice and policy·2026
Same author

Berbamine sensitizes hepatocellular carcinoma to chemotherapy by inhibiting autophagy <i>via</i> modulating SIRT1-mediated acetylation.

Frontiers in pharmacology·2026
Same author

Smartphone Keystroke Biomarkers as Predictors of Adverse Neuropsychiatric Sequelae After Trauma in Trauma Survivors: Prospective Observational Cohort Study.

Journal of medical Internet research·2026
Same author

Peritraumatic C-reactive protein levels predict pain outcomes following traumatic stress exposure in a sex-dependent manner.

The journal of pain·2026
Same author

Social support and post-traumatic stress symptoms: Longitudinal bidirectional relationships in the AURORA study.

Journal of mood and anxiety disorders·2026
Same author

Microbiome functional gene pathways are indicative of cognitive performance in older adults at risk for Alzheimer's disease.

Gut microbes·2026
Same journal

Evidence for progressive neurodegeneration in iatrogenic cerebral amyloid angiopathy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Human brain connectome profiles mediate the relationship between pathology burden and clinical phenotypes in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Kat5 cKO mouse replicates biological domain signatures associated with Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Evaluation of CSF and plasma tau species as fluid surrogate candidates for tau PET in prodromal to moderate Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Associations of self-reported obstructive sleep apnea with cognition and dementia risk in cognitively unimpaired middle-aged adults.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Inflammation profiles in Alzheimer's disease relate to cognition and neurodegeneration.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
See all related articles

Related Experiment Video

Updated: Jan 8, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K

Basic Science and Pathogenesis.

Ziyuan Huang1, Vishaldeep Kaur Sekhon2, Ouyang Guo3

  • 1UMass Chan Medical School, Worcester, MA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
PubMed
Summary
This summary is machine-generated.

The Alzheimer's Disease Analysis Model Generation 1 (ADAM-1) provides stable Alzheimer's classification performance, comparable to XGBoost but with significantly reduced variance. This AI framework enhances multi-modal data analysis for Alzheimer's research.

More Related Videos

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

Related Experiment Videos

Last Updated: Jan 8, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K
A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

Area of Science:

  • Artificial Intelligence in Medicine
  • Neurodegenerative Disease Research
  • Computational Biology and Bioinformatics

Background:

  • Alzheimer's disease (AD) is a complex neurodegenerative disorder with intricate interactions between clinical, microbial, and other factors.
  • Analyzing diverse, multi-modal datasets for AD prognosis presents significant challenges.
  • Existing research often struggles with the complexity and scale of integrated data analysis.

Purpose of the Study:

  • To introduce the Alzheimer's Disease Analysis Model Generation 1 (ADAM-1), a novel multi-agent large language model (LLM) framework.
  • To enhance diagnostic and analytical capabilities for Alzheimer's disease by integrating clinical, microbiome, and literature data.
  • To provide unified and comprehensive insights into Alzheimer's disease prognosis through advanced AI techniques.

Main Methods:

  • Utilized a multi-modal dataset comprising clinical and gut microbiome data from 102 nursing home residents (38 AD, 64 healthy controls).
  • Developed ADAM-1 using GPT-4o-mini-2024-07-18, integrating three AI agents for descriptive statistics, data synthesis, and binary classification.
  • Employed retrieval-augmented generation (RAG) with 80,909 PubMed publications; assessed performance via F1 scores and compared against XGBoost.

Main Results:

  • ADAM-1 achieved a mean F1 score comparable to XGBoost for Alzheimer's classification (p=0.0967).
  • Demonstrated significantly reduced F1 score variance (p=0.0083), indicating more stable and reliable performance.
  • Highlighted ADAM-1's reliability in handling small sample sizes, crucial for clinical translational research.

Conclusions:

  • ADAM-1 provides a robust and consistent platform for multi-modal data analysis in Alzheimer's research.
  • Natural language interaction enhances data interpretability, broadening researchers' insights.
  • Future iterations will incorporate blood biomarkers and neuroimaging for more precise diagnostics and deeper understanding of AD mechanisms.