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Basic Science and Pathogenesis.

Alesia V Prakapenka1

  • 1Midwestern University, Downers Grove, IL, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
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Summary
This summary is machine-generated.

Maternal age and Alzheimer's disease (AD) genotype impact maternal behaviors in female mice. Older AD dams showed deficits in pup retrieval, suggesting AD progression influences maternal care during aging.

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Area of Science:

  • Neuroscience
  • Reproductive Biology
  • Gerontology

Background:

  • Female-specific reproductive events like pregnancy and perimenopause involve significant hormonal shifts.
  • Ovarian hormones influence physiology and behavior, potentially contributing to higher Alzheimer's disease (AD) risk in females.
  • Investigating the interplay of age, pregnancy, and perimenopause on cognitive and behavioral health in female mice is crucial.

Purpose of the Study:

  • To examine how maternal age at first birth affects maternal behaviors in wildtype (WT) and AD mouse models.
  • To assess the impact of perimenopause induction on cognitive and behavioral functions in healthy and AD female mice.
  • To understand the relationship between postnatal and perimenopausal maternal behaviors in female aging trajectories.

Main Methods:

  • Utilized wildtype (WT) and 3xTg-AD mouse models.
  • Assessed maternal behaviors (pup retrieval, home cage care) at different maternal ages (2, 5-6, 9 months).
  • Modeled perimenopause using VCD treatment and evaluated cognitive/behavioral tasks (spatial memory, activity, anxiety, depression).

Main Results:

  • Increasing maternal age at first birth reduced pregnancy success and litter size.
  • Older AD dams (5-6 months) exhibited impaired pup retrieval compared to younger AD dams and WT dams.
  • Maternal care behaviors in the home cage were similar between WT and AD dams across age groups.

Conclusions:

  • Alzheimer's disease genotype and maternal age at first birth significantly modulate postnatal maternal behaviors.
  • Behavioral changes associated with AD progression may influence these maternal behaviors.
  • Further research is needed to explore the full spectrum of maternal behaviors during female aging in healthy and AD contexts.