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Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
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Basic Science and Pathogenesis
Susheel Varma1, Laura M Heath1, Jessica Malenfant1
1Sage Bionetworks, Seattle, WA, USA.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
Summary
The AD Knowledge Portal and Agora provide researchers with extensive data and tools to discover Alzheimer's disease (AD) therapies. These resources accelerate the identification and validation of potential drug targets for AD.
Area of Science:
- Neuroscience and Computational Biology
- Genomics and Bioinformatics
Background:
- Alzheimer's disease (AD) research requires understanding cellular and molecular factors driving disease.
- The AD Knowledge Portal, Exceptional Longevity Portal (ELITE), and Agora are key resources for this research.
Purpose of the Study:
- To support researchers in identifying molecular hypotheses and mechanisms for AD.
- To facilitate the evaluation of these hypotheses through experimental assessments.
- To prioritize molecular mechanisms for therapeutic development in AD.
Main Methods:
- Utilizing a vast repository of data from over 41,000 biospecimens across four species.
- Providing access to analytical results for potential drug targets.
- Integrating with external Trusted Research Environments (TREs) like CAVATICA, Terra, and AD Workbench.
Main Results:
- The Portal supports research from 55 grants, including the Accelerating Medicines Partnership-Alzheimer's Disease.
- Data spans over 55 assays (genomics, metabolomics, imaging, cognitive assessments) from diverse sources.
- Includes iPSC-derived cell types, organoids, and novel Late-Onset AD mouse models, alongside a cloud-based analytical workspace and Agora for visual data exploration.
Conclusions:
- The AD Knowledge Portal, ELITE Portal, and Agora offer researchers accessible and comprehensive data, tools, and results.
- These platforms are crucial for advancing Alzheimer's disease research and therapeutic development.
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